An Universal packaging technique for low-drift implantable pressure sensors.
An Universal packaging technique for low-drift implantable pressure sensors.
复制标题
一种用于低矮植入压力传感器的通用包装技术。
DOI：
10.1007/s10544-016-0058-y
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发表时间：
2016-04
影响因子：
2.8
通讯作者：
Ziaie B
中科院分区：
文献类型：
--
作者：
Kim A;Powell CR;Ziaie B
监测身体压力提供了有价值的诊断和预后信息。特别地，在经皮进入可能复杂或危险的情况下（例如，脑积水患者的颅内压）。尽管在微型固态压力传感器的制造方面取得了数十年的进展，但传感器漂移迄今为止严重限制了它们在植入式系统中的应用。在本文中，我们报告了一种通用的封装技术，以减少传感器的漂移。所描述的方法将压力传感器与漂移的主要来源隔离，通过将传感器封装在填充硅胶的医用级聚氨酯气球中，与周围水性环境接触。使用商业微机械压阻式压力传感器进行的100天体外浸泡测试证明了稳定的操作，输出保持在参考压力传感器的1.8 cmH 2 O（1.3 mmHg）范围内。在类似的测试条件下，非隔离传感器在参考值的10-20 cmH 2 O（7.4-14.7 mmHg）之间波动，从未稳定到稳定的操作状态。在Ossabow猪中的植入证明了包装的稳健性及其在减少基线漂移方面的体内有效性。
Monitoring bodily pressures provide valuable diagnostic and prognostic information. In particular, long-term measurement through implantable sensors is highly desirable in situations where percutaneous access can be complicated or dangerous (e.g., intracranial pressure in hydrocephalic patients). In spite of decades of progress in the fabrication of miniature solid-state pressure sensors, sensor drift has so far severely limited their application in implantable systems. In this paper, we report on a universal packaging technique for reducing the sensor drift. The described method isolates the pressure sensor from a major source of drift, i.e., contact with the aqueous surrounding environment, by encasing the sensor in a silicone-filled medical-grade polyurethane balloon. In-vitro soak tests for 100 days using commercial micromachined piezoresistive pressure sensors demonstrate a stable operation with the output remaining within 1.8 cmH2O (1.3 mmHg) of a reference pressure transducer. Under similar test conditions, a non-isolated sensor fluctuates between 10–20 cmH2O (7.4–14.7 mmHg) of the reference, without ever settling to a stable operation regime. Implantation in Ossabow pigs demonstrate the robustness of the package and its in-vivo efficacy in reducing the baseline drift.