Chronic inflammation, albuminuria, and functional disability in older adults with cardiovascular disease: The National Health and Nutrition Examination Survey, 1999-2008
Chronic inflammation, albuminuria, and functional disability in older adults with cardiovascular disease: The National Health and Nutrition Examination Survey, 1999-2008
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DOI：
10.1016/j.atherosclerosis.2012.03.004
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发表时间：
2012-06-01
期刊：
影响因子：
5.3
通讯作者：
Raji, Mukaila A.
中科院分区：
文献类型：
--
作者：
Kuo, Hsu-Ko;Al Snih, Soham;Raji, Mukaila A.
Objective: Although C-reactive protein (CRP) and albuminuria are well-documented cardiovascular risk markers, the functional implications of these biomarkers and their combination on functional disability and metabolic risks in patients with cardiovascular disease (CVD) are unknown.Methods: Data were from 1403 adults (>= 60 years, mean 73.2 years) with CVD, ascertained by self-reported diagnosis of angina, coronary heart disease, congestive heart failure, myocardial infarction or stroke, in the National Health and Nutrition Examination Survey 1999-2008. Disability in activities of daily living (ADL), instrumental activities of daily living (IADL), leisure and social activities (LSA), general physical activities (GPA), and lower-extremity mobility (LEM) were obtained from self-reports. The urinary albumin-to-creatinine ratio (UACR) was calculated by dividing the urinary albumin value by the urinary creatinine concentration. CRP levels were quantified by latex-enhanced nephelometry.Results: Inflammation and albuminuria were associated with disability. In the full-adjusted models, odds ratios (ORs) (95% confidence intervals [CIs]) of disability in ADL, LSA, and LEM were 1.60 (1.13-2.28), 1.76 (1.22-2.55) and 2.31 (1.62-3.31), respectively, comparing participants in the highest CRP quartile to the lowest (p values for trend across CRP quartiles
