Ground squirrels initiate sexual maturation during hibernation
Ground squirrels initiate sexual maturation during hibernation
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地松鼠在冬眠期间启动性成熟
DOI：
10.1016/j.cub.2022.02.032
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发表时间：
2022
期刊：
影响因子：
9.2
通讯作者：
Gracheva, Elena O.
中科院分区：
文献类型：
--
作者：
Dai Pra, Rafael;Mohr, Sarah M.;Merriman, Dana K.;Bagriantsev, Sviatoslav N.;Gracheva, Elena O.
充足的营养对于正常的生殖功能至关重要，这对物种的生存至关重要。在人类和其他哺乳动物中，饥饿和营养不足会耗尽脂肪储备，导致体重减轻，削弱生殖轴的功能，并导致性腺功能减退。1 - 4十三行地松鼠（Ictidomys tridecemlineatus）每年有7个月处于冬眠状态，没有食物和水。冬眠的松鼠在休眠和间歇唤醒（IBA）之间交替，当动物暂时恢复到类似活动的状态时，IBA的生理意义尚不清楚，但它被认为是冬眠动物在休眠期间体温下降到2°C-4°C的必要条件。在这里，我们报告说，少年雄性地松鼠开始生殖成熟在他们的第一个冬眠季节，尽管长期营养不良和体重严重下降。我们发现，下丘脑生殖轴在冬眠中的interbout觉醒过程中经历激活，触发促黄体生成素和睾酮的产生，并促进睾丸生长。性成熟的启动是周期性的，并且与生理状态、环境温度和食物供应无关。我们的研究表明，在冬眠期间，interbout唤醒的作用，并揭示了在极端负能量平衡条件下生殖轴激活的神经生理机制。视频摘要
Adequate nutrition is essential for normal reproductive function, which is vital for species to survive. In humans and other mammals, starvation and undernutrition deplete fat reserves and cause weight loss, attenuating the function of the reproductive axis and causing hypogonadism.1–4Thirteen-lined ground squirrels (Ictidomys tridecemlineatus) spend 7 months of every year in hibernation without food and water. Hibernating squirrels alternate between periods of torpor and interbout arousal (IBA), when animals temporarily return to an active-like state.5The physiological significance of IBA is unclear, but it is thought to be essential for hibernation in animals that drop their body temperature to 2°C–4°C during torpor. Here, we report that juvenile male ground squirrels initiate reproductive maturation during their first hibernation season, despite prolonged undernutrition and profound weight loss. We show that the hypothalamic reproductive axis undergoes activation during interbout arousals in the middle of hibernation, triggering production of luteinizing hormone and testosterone, and promoting testicular growth. Initiation of sexual maturation is circannually entrained and is independent of physiological state, ambient temperature, and food availability. Our study suggests a role for interbout arousals during hibernation and uncovers the neurophysiological mechanism of reproductive axis activation during conditions of extreme negative energy balance.Video abstract
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早期和后期幼年宿舍之间生长速率和预见前体重增益的差异。
DOI：
10.1007/s00360-016-1017-x
发表时间：
2017-01
期刊：
Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology
影响因子：
--
作者：
Stumpfel S;Bieber C;Blanc S;Ruf T;Giroud S
通讯作者：
Giroud S
生成时间衡量生命周期中生存和繁殖之间的权衡
影响因子：
2.9
作者：
Stefano Giaimo;A. Traulsen
通讯作者：
A. Traulsen
蛋白质热量营养不良男性的垂体-性腺轴。
影响因子：
5.8
作者：
Stephen R. Smith;M. Chhetri;Ann J. Johanson;Nezam Radfar;Claude J. Migeon
通讯作者：
Claude J. Migeon
DOI：
10.1210/jcem.81.12.8954042
发表时间：
1996-12
期刊：
The Journal of clinical endocrinology and metabolism
影响因子：
--
作者：
L. Katznelson;J. Finkelstein;D. Schoenfeld;D. Rosenthal;E. Anderson;A. Klibanski
通讯作者：
L. Katznelson;J. Finkelstein;D. Schoenfeld;D. Rosenthal;E. Anderson;A. Klibanski
饥饿对大鼠睾酮-黄体生成素反馈的影响。
DOI：
10.1530/acta.0.0960413
发表时间：
1981
期刊：
Acta endocrinologica
影响因子：
--
作者：
K. Pirke;B. Spyra
通讯作者：
B. Spyra