Low genetic polymorphism of merozoite surface proteins 7 and 10 in Colombian Plasmodium vivax isolates
Low genetic polymorphism of merozoite surface proteins 7 and 10 in Colombian Plasmodium vivax isolates
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DOI：
10.1016/j.meegid.2010.12.002
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发表时间：
2011-03-01
影响因子：
3.2
通讯作者：
Patarroyo, Manuel A.
中科院分区：
文献类型：
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作者：
Garzon-Ospina, Diego;Romero-Murillo, Liza;Patarroyo, Manuel A.
裂殖子表面蛋白（MSP）家族参与疟原虫裂殖子与红细胞的初始相互作用，因此其成员成为疫苗开发的主要靶点。考虑到包括在亚单位疟疾疫苗的抗原应该都是可访问的免疫系统和缺乏遗传多样性或具有非常有限的多态性，我们分析了三个MSP基因（MSP-7A，MSP-7 K和MSP-10）在哥伦比亚的不同地理区域的遗传多样性。结果表明，这些基因遵循中性进化模型，也显示出较低的遗传多样性。在来自不同地理区域的分离株中发现的msp-7单倍型的强保守性进一步表明，这些蛋白质可能是抗间日疟原虫疟疾疫苗的良好组分，从而避免菌株特异性免疫应答。(C)2010 Elsevier B. V.保留所有权利。
The merozoite surface protein (MSP) family is involved in the initial interaction between merozoites and erythrocytes in Plasmodium species, its members are therefore becoming major targets for vaccine development. Considering that antigens included in a subunit malaria vaccine should be both accessible to the immune system and lack genetic diversity or have very limited polymorphism, we have analyzed the genetic diversity of three msp genes (msp-7A, msp-7K and msp-10) in different geographical regions of Colombia. The results showed that these genes follow the neutral model of evolution and also display low genetic diversity. The strong conservation found for msp-7 haplotypes in isolates from geographically different regions further suggests that these proteins could be good components of a vaccine against Plasmodium vivax malaria, thereby avoiding strain-specific immune responses. (C) 2010 Elsevier B.V. All rights reserved.