Bioengineering Lantibiotics for Therapeutic Success.
Bioengineering Lantibiotics for Therapeutic Success.
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DOI：
10.3389/fmicb.2015.01363
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发表时间：
2015
影响因子：
5.2
通讯作者：
Ross RP
中科院分区：
文献类型：
--
作者：
Field D;Cotter PD;Hill C;Ross RP
已经描述了高度修饰的抗微生物肽的几个实例。虽然许多这样的肽是非核糖体合成的，但核糖体合成的等同物正以增加的频率被发现。在后一组中，羊毛硫抗生素继续吸引最多的注意力。在本综述中，我们讨论了体内和体外工程系统的实施，以改变，甚至增强，抗菌活性，抗菌谱和物理化学性质，包括热稳定性，溶解性，扩散和蛋白酶抗性，这些化合物。此外，我们还讨论了这些羊毛硫抗生素作为治疗药物的潜在应用。
Several examples of highly modified antimicrobial peptides have been described. While many such peptides are non-ribosomally synthesized, ribosomally synthesized equivalents are being discovered with increased frequency. Of the latter group, the lantibiotics continue to attract most attention. In the present review, we discuss the implementation of in vivo and in vitro engineering systems to alter, and even enhance, the antimicrobial activity, antibacterial spectrum and physico-chemical properties, including heat stability, solubility, diffusion and protease resistance, of these compounds. Additionally, we discuss the potential applications of these lantibiotics for use as therapeutics.