Spatial heterogeneity of the relation between resting-state connectivity and blood flow: An important consideration for pharmacological studies
Spatial heterogeneity of the relation between resting-state connectivity and blood flow: An important consideration for pharmacological studies
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DOI：
10.1002/hbm.22224
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发表时间：
2014-03-01
影响因子：
4.8
通讯作者：
Rombouts, Serge A. R. B.
中科院分区：
文献类型：
--
作者：
Khalili-Mahani, Najmeh;van Osch, Matthias J.;Rombouts, Serge A. R. B.
静息态功能磁共振成像（RSfMRI）和动脉自旋标记（ASL）为研究脑功能连接或脑血流量（CBF）方面的脑活动状态提供了药理学神经成像工具。功能连接反映了大脑网络中自发波动的同步性或相关性程度-主要是血氧水平依赖（BOLD）信号;但CBF反映了动脉血随时间向脑组织的平均输送。BOLD和CBF信号与常见的神经血管和血液动力学机制有关，这些机制需要增加向神经元激活部位的氧运输;然而，静态CBF和时空BOLD相关性的变化的规模和来源可能不同。我们通过检查CBF和静息状态网络一致性（RSNC）之间的关系来验证这一假设-代表平均内部网络连接，通过双回归分析确定8个标准网络的兴趣（NOI）-在吗啡和酒精的交叉安慰剂对照研究中。总体而言，我们观察到RSNC和CBF之间的空间异质性关系，以及实验因素（药物-时间，时间，药物和生理速率）和每个这些指标之间的关系。药物对CBF的时间效应在所有网络中均显著，但RSNC的显著变化仅限于感觉运动、执行/突显和工作记忆网络。事后体素统计显示类似的解离，可能表明RSNC和CBF对药物作用的神经元和血管终点的敏感性不同。RSNC/CBF关系的空间异质性鼓励进一步研究神经受体分布和脑血管解剖在预测药物下自发波动中的作用。《脑地图》35：929-942，2014年。(c)2012 Wiley Periodicals，Inc.
Resting state fMRI (RSfMRI) and arterial spin labeling (ASL) provide the field of pharmacological Neuroimaging tool for investigating states of brain activity in terms of functional connectivity or cerebral blood flow (CBF). Functional connectivity reflects the degree of synchrony or correlation of spontaneous fluctuations-mostly in the blood oxygen level dependent (BOLD) signal-across brain networks; but CBF reflects mean delivery of arterial blood to the brain tissue over time. The BOLD and CBF signals are linked to common neurovascular and hemodynamic mechanisms that necessitate increased oxygen transportation to the site of neuronal activation; however, the scale and the sources of variation in static CBF and spatiotemporal BOLD correlations are likely different. We tested this hypothesis by examining the relation between CBF and resting-state-network consistency (RSNC)-representing average intranetwork connectivity, determined from dual regression analysis with eight standard networks of interest (NOIs)-in a crossover placebo-controlled study of morphine and alcohol. Overall, we observed spatially heterogeneous relations between RSNC and CBF, and between the experimental factors (drug-by-time, time, drug and physiological rates) and each of these metrics. The drug-by-time effects on CBF were significant in all networks, but significant RSNC changes were limited to the sensorimotor, the executive/salience and the working memory networks. The post-hoc voxel-wise statistics revealed similar dissociations, perhaps suggesting differential sensitivity of RSNC and CBF to neuronal and vascular endpoints of drug actions. The spatial heterogeneity of RSNC/CBF relations encourages further investigation into the role of neuroreceptor distribution and cerebrovascular anatomy in predicting spontaneous fluctuations under drugs. Hum Brain Mapp 35:929-942, 2014. (c) 2012 Wiley Periodicals, Inc.