The effects of cocaine on depressed patients.
The effects of cocaine on depressed patients.
复制标题
可卡因对抑郁症患者的影响。
DOI：
--
复制
发表时间：
1974
影响因子：
17.7
通讯作者：
F. Goodwin
中科院分区：
文献类型：
--
作者：
R. Post;J. Kotin;F. Goodwin
内源性抑郁症患者口服可卡因对生命体征或抑郁症状没有持续影响，但确实减少了快速眼动睡眠和总睡眠时间。当在治疗性访谈中静脉给药时，可卡因引起脉搏和血压急剧增加，并伴有情感和眼泪的深刻调动。导致生命体征变化较小的输液与轻度的情感变化和较少的烦躁有关。因此，虽然可卡因能够在抑郁症患者中引起积极的情感变化（如平静和兴奋），但情感泛滥和烦躁的成分往往是混合的，这表明可卡因在这种情况下的作用不能简单地归类为抗抑郁药。
Cocaine, administered orally to patients with endogenous depressive illness, did not consistently affect vital signs or depressive symptomatology, but it did decrease rapid eye movement sleep and total sleep time. When administered intravenously in the context of a therapeutic interview, cocaine caused large, rapid increases in pulse and blood pressure concomitant with profound mobilization of affect and tearfulness. Infusions that caused lesser changes in vital signs were associated with milder degrees of affective change and less dysphoria. Thus, while cocaine was capable of eliciting positive affective change (such as calmness and elation) in depressed patients, affective flooding and dysphoric components were often admixed, indicating that cocaine's effect in this context could not be classified simply as antidepressant.