Advances in apoptosis-related genes in the silkworm, Bombyx mori
Advances in apoptosis-related genes in the silkworm, Bombyx mori
复制标题
DOI：
10.16380/j.kcxb.2017.04.013
复制
发表时间：
2017-04-01
期刊：
影响因子：
--
通讯作者：
Lu Cheng
中科院分区：
文献类型：
--
作者：
Bao Xi-Yan;Chen Peng;Lu Cheng
细胞凋亡是通过基因调控维持细胞内稳态的细胞自主死亡。家蚕是鳞翅目的重要模型，研究家蚕的细胞凋亡机制具有代表性意义。家蚕的细胞凋亡不仅参与变态，而且参与自然免疫。凋亡通过调控凋亡相关基因，在家蚕卵-幼虫-蛹-成虫阶段促进组织降解和去除多余细胞，抑制家蚕核多角体病毒（BmNPV）增殖等方面发挥重要作用。本文就近年来家蚕的凋亡诱导因子、凋亡相关基因和途径以及凋亡对家蚕发育的影响等方面的研究进展进行综述，有助于深入解决家蚕凋亡机制研究不足、内质网途径探索较少、各途径间联系不清等问题。为研究家蚕的变态机制和自身免疫系统奠定基础。
Apoptosis is the cell autonomic decease by gene controlling to maintain the homeostasis of cells. Studying the mechanisms of apoptosis in the silkworm, Bombyx mori, an important model of Lepidoptera, has the representative significance. Apoptosis in the silkworm not only participates in the metamorphosis, but also in the natural immunity. Apoptosis plays an important role in promoting tissue degradation and removing redundant cells in the egg-larva-pupa-adult stages of B. mori through the regulation of apoptosis-related genes, and in the inhibition of B. mori nucleopolyhedrovirus (BmNPV) proliferation. In this article we reviewed the advances in the apoptosis-inducing factors, apoptosis-related genes and pathways in B. mori, and the effects of apoptosis on the development of B. mori in recent years, which will facilitate to deeply resolve such problems as the mechanism research on apoptosis not enough, the pathway of endoplasmic reticulum rarely explored and the linkage between various pathways unclear and so on, and lay the foundation for studying the mechanism of metamorphosis and the system of autoimmune in B. mori.