Evaluation of a Porous Bioabsorbable Interbody Mg-Zn Alloy Cage in a Goat Cervical Spine Model
Evaluation of a Porous Bioabsorbable Interbody Mg-Zn Alloy Cage in a Goat Cervical Spine Model
复制标题
多孔生物可吸收椎间镁锌合金笼在山羊颈椎模型中的评价
DOI：
10.1155/2018/7961509
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发表时间：
2018-01-01
影响因子：
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通讯作者：
Jiang, Jianyuan
中科院分区：
文献类型：
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作者：
Xu, Haocheng;Zhang, Fan;Jiang, Jianyuan
生物可吸收的镁基植入物由于其固有的优势而被先前评估，但镁基笼相关的研究有限。特定的血液供应和椎间环境的压力会影响镁基植入物的功能。本研究的目的是研究生物可吸收Mg-Zn合金笼在前路颈椎椎间盘切除术和融合（ACDF）中的性能，并评估在椎间微环境下，含Si微弧氧化（MAO）技术修饰的Mg-Zn笼表面降解的控制。方法24只山羊按试验周期分为4组，分别在C2-3和C4-5椎间隙采用多孔Mg-Zn笼，其中一个椎间隙采用含MAO/ si涂层，另一个椎间隙采用自体髂骨。术后3周、6周、12周或24周采集颈椎标本，通过血液分析、放射学、生物力学测试、组织学和显微ct评估生物相容性、融合状态和降解情况。结果镁锌笼具有理想的生物相容性和生物力学性能；然而，放射学和组织学评估的融合状态是不可接受的。经含MAO/ si涂层改性后，Mg-Zn笼的降解速度可控，但低于预期。结论MAO/ si包覆Mg-Zn合金笼术后24周表现出良好的降解和融合失效控制。我们的结论是，应该设计进一步的研究来改善在椎间隙使用镁基材料。
Purpose Bioabsorbable Mg-based implants were previously assessed due to their intrinsic advantages, but Mg-based cage related research is limited. The specific blood supply and stress of the intervertebral environment can affect the function of Mg-based implants. The objective of this study was to investigate the performance of a bioabsorbable Mg-Zn alloy cage in anterior cervical discectomy and fusion (ACDF) and evaluate the control of degradation of the Mg-Zn cage surface modified by microarc oxidation (MAO) technology containing Si under an intervertebral microenvironment. Methods Twenty-four goats were divided into four groups according to the experimental period and all underwent ACDF at C2-3 and C4-5 with porous Mg-Zn cage covered with a MAO/Si-containing coating in one intervertebral space and with autologous iliac bone in another space. After 3, 6, 12, or 24 weeks after operation, the cervical spine specimens were harvested to evaluate the biocompatibility, fusion status, and degradation conditions using blood analysis, radiology, biomechanical testing, histology, and micro-CT. Results The Mg-Zn cages showed ideal biocompatibility and biomechanical characterization; however, the fusion state, as evaluated with radiology and histology, was not acceptable. Modified by the MAO/Si-containing coating, the degradation rate of the Mg-Zn cages was controllable but slower than expected. Conclusion MAO/Si-containing coating Mg-Zn alloy cages demonstrated excessive control of degradation and fusion failure after 24 weeks postoperatively. We conclude that further studies should be designed to improve the using of Mg-based materials at the intervertebral space.