Racial differences in adiponectin in youth - Relationship to visceral fat and insulin sensitivity
Racial differences in adiponectin in youth - Relationship to visceral fat and insulin sensitivity
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DOI：
10.2337/diacare.29.01.06.dc05-0952
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发表时间：
2006-01-01
期刊：
影响因子：
16.2
通讯作者：
Arslanian, SA
中科院分区：
文献类型：
--
作者：
Lee, S;Bacha, F;Arslanian, SA
目的-本研究的目的是调查1）脂联素是否与非裔美国人和白人青年的胰岛素敏感性相关，而独立于内脏脂肪组织，以及2）脂联素是否与胰岛素敏感性的种族差异相关。研究设计和方法-通过双能X射线吸收测定法测量全身脂肪，并通过计算机断层扫描测量腹部脂肪组织。胰岛素敏感性通过3-h高胰岛素-正葡萄糖钳夹测定。结果-脂联素与内脏脂肪组织、空腹胰岛素和胰岛素原呈负相关（P < 0.01），在控制坦纳分期和性别后与胰岛素敏感性呈正相关（P < 0.01），与种族无关。逐步多元回归分析显示，脂联素是胰岛素敏感性的一个强有力的独立预测因子，可解释27%的胰岛素敏感性变异。当受试者被分为内脏脂肪组织三分位数组和更低（第50）脂联素组时，两个种族的内脏脂肪组织组之间的胰岛素敏感性存在显著差异（主效应，P < 0.01）。然而，在每个内脏脂肪组织组中，高脂联素受试者的胰岛素敏感性（主效应，P < 0.05）高于低脂联素受试者，与种族无关。在控制了瘦素和内脏脂肪组织后，胰岛素敏感性的种族差异仍然显著（P < 0.01），但在额外调整了脂联素后，差异不显著（P > 0.05）。结论：在非裔美国人和白人青年中，脂联素与胰岛素敏感性相关，与内脏脂肪组织无关。非洲裔美国青年的低脂联素可能是使他们更容易患胰岛素抵抗的生物标志物。
OBJECTIVE - The purpose of this study was to investigate 1) whether adiponectin is associated with insulin sensitivity independent of visceral adipose tissue in African-American and Caucasian youth and 2) whether adiponectin is associated with racial differences in insulin sensitivity.RESEARCH DESIGN AND METHODS - Total body fat was measured by dual-energy X-ray absorptiometry and abdominal adipose tissue with computed tomography. Insulin sensitivity was measured by a 3-h hyperinsulinemic-euglycemic clamp.RESULTS - Adiponectin was inversely associated (P < 0.01) with visceral adipose tissue, fasting insulin, and proinsulin and was positively related (P < 0.01) to insulin sensitivity after controlling for Tanner stage and sex independent of race. Stepwise multiple regression revealed that adiponectin was a strong independent predictor of insulin sensitivity, explaining 27% of the variance in insulin sensitivity. When subjects were categorized into tertiles of visceral adipose tissue and further low ( 50th) adiponectin groups, insulin sensitivity was significantly different across the visceral adipose tissue groups (main effect, P < 0.01) in both races. However, within each visceral adipose tissue group, subjects with high adiponectin had higher insulin sensitivity (main effect, P < 0.05) than subjects with low adiponectin, independent of race. Racial differences in insulin sensitivity remained significant (P < 0.01) after controlling for leptin and visceral adipose tissue but not (P > 0.05) after additional adjustment for adiponectin.CONCLUSIONS - Adiponectin is associated with insulin sensitivity independent of visceral adipose tissue in both African-American and Caucasian youth. Low adiponectin in African-American youth may be a biological marker that predisposes them to a greater risk of insulin resistance.