Body-mass index and incidence of cancer: a systematic review and meta-analysis of prospective observational studies
Body-mass index and incidence of cancer: a systematic review and meta-analysis of prospective observational studies
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DOI：
10.1016/s0140-6736(08)60269-x
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发表时间：
2008-02-16
期刊：
影响因子：
168.9
通讯作者：
Zwahlen, Marcel
中科院分区：
文献类型：
--
作者：
Renehan, Andrew G.;Tyson, Margaret;Zwahlen, Marcel
研究背景：体重超重，以身体质量指数（BMI）的增加来表示，与一些常见的成人癌症的风险有关。我们进行了系统回顾和荟萃分析，以评估BMI与不同癌症部位之间的关联强度，并调查这些关联在性别和种族群体之间的差异。方法在Medline和Embase上进行电子检索（1966年至2007年11月），并检索报告以确定20种癌症类型事件病例的前瞻性研究。我们对研究特定增量估计进行了随机效应荟萃分析和荟萃回归，以确定与BMI增加5 kg/m(2)相关的癌症风险。我们分析了221个数据集（141篇文章），包括282137个事件病例。在男性中，体重指数每增加5kg /m(2)与食管癌密切相关(RR 1.52, p
Background Excess bodyweight, expressed as increased body-mass index (BMI), is associated with the risk of some common adult cancers. We did a systematic review and meta-analysis to assess the strength of associations between BMI and different sites of cancer and to investigate differences in these associations between sex and ethnic groups.Methods We did electronic searches on Medline and Embase (1966 to November 2007), and searched reports to identify prospective studies of incident cases of 20 cancer types. We did random-effects meta-analyses and meta-regressions of study-specific incremental estimates to determine the risk of cancer associated with a 5 kg/m(2) increase in BMI.Findings We analysed 221 datasets (141 articles), including 282137 incident cases. In men, a 5 kg/m(2) increase in BMI was strongly associated with oesophageal adenocarcinoma (RR 1.52, p