A pilot study of dextromethorphan in naloxone-precipitated opiate withdrawal.
A pilot study of dextromethorphan in naloxone-precipitated opiate withdrawal.
复制标题
右美沙芬在纳洛酮促阿片戒断中的初步研究。
DOI：
10.1016/0014-2999(96)00249-x
复制
发表时间：
1996
影响因子：
5
通讯作者：
Kosten,TR
中科院分区：
文献类型：
--
作者：
Rosen,MI;McMahon,TJ;Woods,SW;Pearsall,HR;Kosten,TR
在临床前研究中，右美沙芬及其代谢物右啡烷拮抗N-甲基-d-天冬氨酸（NMDA）介导的活性。我们研究了在稳定于25 mg美沙酮的阿片类药物依赖受试者中，美沙芬对纳洛酮诱发的阿片类药物戒断的影响。受试者在三个不同日期接受0.4 mg纳洛酮肌内注射激发。纳洛酮前1小时的预治疗是采用双盲、平衡、随机设计的曲美沙芬，6例受试者接受安慰剂、曲美沙芬60 mg或曲美沙芬120 mg; 5例受试者接受安慰剂、曲美沙芬120 mg或曲美沙芬240 mg。对美沙芬的反应存在相当大的个体间变异性，但在评估的任何戒断措施中，美沙芬均无净衰减。2/3例美沙酮脱毒受试者（每4小时口服60 mg美沙芬）表现出相当大的戒断症状。
Dextromethorphan and its metabolite dextrorphan antagonize N-methyl-d-aspartate (NMDA)-mediated activity in pre-clinical studies. We examined dextromethorphan's effects on naloxone-precipitated opiate withdrawal in opiate-dependent subjects stabilized on 25 mg of methadone. Subjects received challenges on three different days with 0.4 mg of intramuscular naloxone. Pretreatment 1 h before naloxone was with dextromethorphan in a double-blind, balanced, randomized design with either placebo, dextromethorphan 60 mg, or dextromethorphan 120 mg for six subjects; and placebo, dextromethorphan 120 mg, or dextromethorphan 240 mg for five subjects. There was considerable inter-individual variability in the response to dextromethorphan, but no net attenuation by dextromethorphan on any withdrawal measure assessed. Two of three subjects detoxified from methadone with dextromethorphan 60 mg orally every 4 h demonstrated considerable withdrawal.