Invasive aspergillosis in the intensive care unit
Invasive aspergillosis in the intensive care unit
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DOI：
10.1111/j.1749-6632.2012.06805.x
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发表时间：
2012-01-01
期刊：
影响因子：
--
通讯作者：
Armaganidis, Apostolos
中科院分区：
文献类型：
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作者：
Dimopoulos, George;Frantzeskaki, Frantezeska;Armaganidis, Apostolos
侵袭性曲霉菌病是一种严重影响免疫功能低下患者的毁灭性感染，最常见的是恶性血液病。近年来，侵袭性曲霉菌病的发病率激增已报告的危重患者没有经典的危险因素。重症监护室（ICU）患者的死亡率同样高，而临床体征和症状无特异性，诊断仍然是一个挑战。新的非侵入性诊断方法结合耐受性更好的抗真菌药物旨在早期诊断侵袭性曲霉病并改善预后。在这篇综述中，我们讨论了流行病学，诊断策略和算法，以及治疗选择这种严重感染的危重患者。
Invasive aspergillosis is a devastating infection affecting severely immunocompromised patients, most frequently with hematologic malignancies. In recent years, a surge in the incidence of invasive aspergillosis has been reported in critically ill patients without the classical risk factors. The mortality of the disease is equally high in the group of intensive care unit (ICU) patients, while the clinical signs and symptoms are nonspecific and the diagnosis remains a challenge. New noninvasive diagnostic methods in combination with better tolerated antifungal drugs aim for early diagnosis and improved prognosis of invasive aspergillosis. In this review, we discuss the epidemiology, the diagnostic strategy and algorithms, and the therapeutic choices of this severe infection in critically ill patients.