A historical perspective on the immunodiagnosis of schistosomiasis in China
A historical perspective on the immunodiagnosis of schistosomiasis in China
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DOI：
10.1016/s0001-706x(02)00010-4
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发表时间：
2002-05-01
期刊：
影响因子：
2.7
通讯作者：
Wu, GL
中科院分区：
文献类型：
--
作者：
Wu, GL
中国对血吸虫病免疫诊断的研究和应用，至今已有近50年的历史。在本文中，作者简要回顾了我国所涉及的技术进展，重点介绍了近十年来的最新问题。通过总结一些合作研究，试图确定血吸虫病免疫诊断中血清学的实施指南，也表明了疾病控制计划的使用存在一些局限性。此外，有人指出，在确定接受治疗或再治疗的目标个人时采用血清学方法可能是现实和实用的，强调公共卫生使用的免疫诊断方法可能会忽视对真实感染的个人识别。这样，就有可能绕过解释个体血清反应性的复杂性，将他/她的定性测试分配给正常或感染的人。相反，人们只需要根据滴度分布将社区中的个人分为“正常”或“感染”组，这将导致确定治疗的目标群体。(C)2002 Elsevier Science B.V.保留所有权利。
The investigation and application of immunodiagnosis in schistomiasis have had a history of about 50 years so far in China. The author, in this paper, briefly review the progress of the technology involved here in the country, putting the stress on the latest issues during last decade. Also showed some limits in the use for control program of the disease through summary of some collaborative studies with the attempt in identifying guidelines for the implementation of serology in schistosomiasis immunodiagnosis. In addition, it was pointed out that a seroepidentiological approach in the identification of target individuals for treatment or re-treatment may be realistic and practical, which emphasized that the immunodiagnostic approach for public health use could ignore individual identification of the real infections. In this way, it became possible to bypass the complexity of interpreting the seroreactivity of an individual in assigning him/her with qualitative testing to the normal or infected person. Instead, one needs only to divide individuals in a community into 'normal' or 'infected' groups according to the titer distribution, which leads to identifying target groups for treatment. (C) 2002 Elsevier Science B.V. All rights reserved.