MAGNESIUM-IONS BLOCK AN N-METHYL-D-ASPARTATE RECEPTOR-MEDIATED COMPONENT OF SYNAPTIC TRANSMISSION IN RAT HIPPOCAMPUS
MAGNESIUM-IONS BLOCK AN N-METHYL-D-ASPARTATE RECEPTOR-MEDIATED COMPONENT OF SYNAPTIC TRANSMISSION IN RAT HIPPOCAMPUS
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DOI：
10.1016/0304-3940(85)90091-6
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发表时间：
1985-01-01
影响因子：
2.5
通讯作者：
COLLINGRIDGE, GL
中科院分区：
文献类型：
--
作者：
COAN, EJ;COLLINGRIDGE, GL
在有和无Mg ~（2+）存在的情况下，研究了N-甲基-d-天冬氨酸（NMDA）受体参与大鼠海马脑片Schaffer侧支-连合通路的突触传递。用无Mg 2+培养基灌注切片导致群体尖峰的振幅增加和多个群体尖峰的出现。一个NMDA拮抗剂，这对突触反应的存在下，Mg 2+没有影响，完全阻止了多重反应的出现。如果加入到已经浸泡在无Mg 2+培养基中的切片中，拮抗剂消除了多重反应，并部分降低了初始群体尖峰的幅度。这些数据表明，在何种程度上NMDA受体参与突触传递在大鼠海马取决于细胞外Mg 2+浓度。
The involvement of N-methyl-d-aspartate (NMDA) receptors in synaptic transmission in the Schaffer collateral-commissural pathway of rat hippocampal slices has been examined in the presence and absence of Mg2+. Superfusion of slices with Mg2+-free medium resulted in an increase in the amplitude of the population spike and the appearance of multiple population spikes. An NMDA antagonist, which had no effect on the synaptic response in the presence of Mg2+, completely prevented the appearance of multiple responses. If added to slices already bathed in Mg2+-free medium, the antagonist eliminated the multiple responses and partly reduced the amplitude of the initial population spike. These data suggest that the extent to which NMDA receptors participate in synaptic transmission in rat hippocampus depends on the extracellular Mg2+concentration.