Menthol desensitization of capsaicin irritation: Evidence of a short-term anti-nociceptive effect
Menthol desensitization of capsaicin irritation: Evidence of a short-term anti-nociceptive effect
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DOI：
10.1016/s0031-9384(99)00221-8
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发表时间：
2000-03-01
影响因子：
2.9
通讯作者：
McAuliffe, BL
中科院分区：
文献类型：
--
作者：
Green, BG;McAuliffe, BL
在研究薄荷醇使口腔对辣椒素敏感的潜力的过程中发现了薄荷醇的短期抗伤害感受作用的证据。先前的研究表明，在暴露于辣椒素之前用薄荷醇处理舌头15分钟可以增强辣椒素的刺激性，我们希望了解这种效果是否会随着暴露于薄荷醇和辣椒素之间的时间减少而增加。相反，我们发现，当辣椒素后薄荷醇只有3.5分钟，或当它与薄荷醇的混合物中存在2-3分钟，感觉刺激减少，而不是增强。在第二个实验中，我们通过改变暴露于薄荷醇和连续三个辣椒素刺激块之间的延迟来检查这种明显的交叉脱敏的持续时间。交叉脱敏倾向于下降的刺激间隔（ISI）增加到5分钟，甚至当脱敏是最大的。它仅对三种辣椒素刺激物中的第一种有意义。在最后的实验中，我们研究了薄荷醇自身和交叉脱敏如何影响薄荷醇-辣椒素混合物的感知。在一系列的五个，90年代的刺激，自我和交叉脱敏变得明显，在第二次曝光的开始，但对混合物强度的影响再次迅速减少刺激继续。我们从这些结果推断，方法可以暂时脱敏辣椒素敏感的纤维，但辣椒素暴露迅速覆盖的效果。这些研究结果的影响，薄荷醇作为局部镇痛药的潜力进行了讨论。(C)2000 Elsevier Science Inc. All rights reserved.
Evidence is presented of a short-term antinociceptive effect of menthol that was discovered in the course of investigating menthol's potential to sensitize the mouth to capsaicin. Previous research had shown that treating the tongue with menthol 15 min before exposure to capsaicin could enhance the irritancy of capsaicin, and we wished to learn if this effect would increase as the time between exposure to menthol and capsaicin decreased. We found instead that when capsaicin followed menthol by only 3.5 min, or when it was presented in mixture with menthol for 2-3 min, sensory irritation was reduced rather than enhanced. We examined the duration of this apparent cross-desensitization in a second experiment by varying the delay between exposure to menthol and a block of three consecutive capsaicin stimuli. Cross-desensitization tended to decline as the interstimulus interval (ISI) increased to 5 min, and even when desensitization was maximal. it was significant only for the first of the three capsaicin stimuli. In the final experiment we investigated how menthol self- and cross-desensitization can influence the perception of menthol-capsaicin mixtures. During a series of five, 90-s stimulations, self- and cross desensitization became evident at the beginning of the second exposure, but the effect on mixture intensity again diminished rapidly as stimulation continued. We infer from these results that method can transiently desensitize capsaicin-sensitive fibers, but that exposure to capsaicin rapidly overrides the effect. The implications these findings have for menthol's potential as a topical analgesic are discussed. (C) 2000 Elsevier Science Inc. All rights reserved.