Development of an effective Edwardsiella tarda vaccine for cultured turbot (Scophthalmus maximus)
Development of an effective Edwardsiella tarda vaccine for cultured turbot (Scophthalmus maximus)
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DOI：
10.1016/j.fsi.2008.05.008
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发表时间：
2008-09-01
影响因子：
4.7
通讯作者：
Magarinos, B.
中科院分区：
文献类型：
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作者：
Castro, N.;Toranzo, A. E.;Magarinos, B.
自2004年以来，迟缓爱德华氏菌已成为欧洲大菱鲆养殖业最重要的新兴病原之一，造成了严重的经济损失。因此，本研究旨在设计一种有效的疫苗接种策略，以防止爱德华氏菌病在这一物种。两种疫苗制剂，一种佐剂疫苗和一种水性疫苗，以及不同的给药途径，浴和腹膜内注射（i.p.），测定了根据相对存活率（RPS）和抗体水平评估不同免疫策略的有效性。根据获得的结果，我们建议通过腹腔注射给予非矿物油佐剂疫苗，其在接种后至少6个月赋予超过90%的RPS值。(c)2008爱思唯尔有限公司保留所有权利。
Since 2004 Edwardsiella tarda has become one of the most important emerging pathogens in turbot aquaculture industry in Europe causing serious economic losses. Therefore, this study aimed to design an effective vaccination strategy to prevent edwardsiellosis in this fish species. Two vaccine formulations, an adjuvanted vaccine and an aqueous bacterin, and different routes of administration, bath and intraperitoneal injection (i.p.), were tested. The effectiveness of the different immunization strategies was evaluated in terms of relative percent survival (RPS) and antibody levels. On the basis of the results obtained we recommend the i.p. administration of a non-mineral oil adjuvanted vaccine via i.p., which confers RPS values over 90% at least 6 months post-vaccination. (c) 2008 Elsevier Ltd. All rights reserved.