Evaluation of Phyllanthus emblica extract on cold pressor induced cardiovascular changes in healthy human subjects.
Evaluation of Phyllanthus emblica extract on cold pressor induced cardiovascular changes in healthy human subjects.
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DOI：
10.4103/0974-8490.122914
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发表时间：
2014-01
影响因子：
0.7
通讯作者：
Pilli R
中科院分区：
文献类型：
--
作者：
Fatima N;Pingali U;Pilli R
急性和慢性应激是冠状动脉疾病发生和发展的危险因素。动脉僵硬增加是心血管疾病的独立标志。冷加压试验(CPT)被认为与自主神经系统的大量激活有关。本研究旨在评价余甘子提取物对冷加压应激试验所致健康受试者心血管参数和主动脉反射的影响。这是一项双盲、安慰剂对照的交叉研究。参与者被随机分成两组，一组服用余甘草提取物250毫克(含有余甘草水提物，经高效液相色谱高度标准化，含有低相对分子质量的可水解单宁灯盏花素-A、灯盏花素-B、淫羊藿素和鹿角豆素)；另一组服用两粒安慰剂，每天两次，共14天。记录CPT前、后及治疗结束时的心率、增强压、增强指数(AIX)、心内膜下存活率(SEVR)、动脉血压(BP)等药效学参数。在14天的洗涤期后，受试者转到另一个治疗组，并再次重复相同的测试程序。安全性评估在基线和治疗结束时进行。共有12名志愿者完成了这项研究。与基础组和安慰剂组相比，余甘子提取液显著降低动脉僵硬指数(AIX、桡动脉和主动脉压)的平均百分变化率，增加CPT心肌灌注指数SERVR。两种疗法的耐受性都很好，没有严重不良反应的报道。独有的余甘子提取物显示，冷加压负荷试验引起的主动脉波反射的变化显著减少。
Acute and chronic stress is a risk factor for the development and progression of coronary artery disease. Increased arterial stiffness is an independent marker for cardiovascular disease. Cold pressor test (CPT) is known to be associated with substantial activation of the autonomic nervous system. The aim of this study was to evaluate the effect of Phyllanthus emblica extract on cold pressor stress test induced changes on cardiovascular parameters and aortic wave reflections in healthy human subjects. This was a double-blind, placebo-controlled, crossover study. Participants were randomized to receive either two capsules of P. emblica extract 250 mg (containing aqueous extract of P. emblica, highly standardized by high-performance liquid chromatography to contain low molecular weight hydrolysable tannins emblicanin-A, emblicanin-B, pedunculagin and punigluconin) or two capsules of placebo twice daily for 14 days. Pharmacodynamic parameters such as heart rate, augmentation pressure, augmentation index (AIx), subendocardial viability ratio (SEVR), radial and aortic blood pressure (BP) were recorded before and after CPT at baseline and end of treatment. After washout period of 14 days, subjects crossed over to the other treatment and the same test procedure was repeated again. Safety assessments were done at baseline and at the end of treatment. A total of 12volunteers completed the study. Compared with baseline and placebo, P. emblica extract produced a significant decrease of mean percent change in the indices of arterial stiffness (AIx, radial and aortic BP) and increase in SEVR, an index of myocardial perfusion with CPT. Both treatments were well-tolerated and no serious adverse events were reported. Proprietary P. emblica extract, showed a significant decrease in cold pressor stress test induced changes on aortic wave reflections.