Extraosseous calcification in patients with chronic renal failure - no escape?
Extraosseous calcification in patients with chronic renal failure - no escape?
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DOI：
10.1093/ndt/gfi030
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发表时间：
2005-10-01
影响因子：
6.1
通讯作者：
Braun, J
中科院分区：
文献类型：
--
作者：
Braun, J
Let me begin by following the advice of the geneticist Luigi Luca Cavalli-Sforza, who stated:‘To understand the present, you have to understand history, and to understand biology you have to understand evolution, because evolution is the history of biology’. Exactly a century ago, MacCallum described the enlarged parathyroid glands of renal failure patients. Thirty years later, Albright observed the related changes in bone histology now known as osteitis fibrosa. Twenty years of therapeutic trials with vitamin D ended with the remarkable sentence of Stanbury, in a Lancet paper published in 1960: subtotal parathyroidectomy is necessary since ‘therapy with vitamin D cannot be relied on to cause involution of the enlarged and possibly autonomous parathyroid glands’. At the end of the 1960s, clinicians’ ability to measure parathyroid hormone (PTH) led to the therapeutic goal of lowering the levels of this hormone, as high levels of secretion by the parathyroid gland had been identified as the cause of secondary hyperparathyroidism. This advance initiated the therapeutic use of activated vitamin D analogues.
