CATECHOLAMINES AND THE COVERT ORIENTATION OF ATTENTION IN HUMANS
CATECHOLAMINES AND THE COVERT ORIENTATION OF ATTENTION IN HUMANS
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DOI：
10.1016/0028-3932(89)90166-8
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发表时间：
1989-01-01
期刊：
影响因子：
2.6
通讯作者：
GEFFEN, LB
中科院分区：
文献类型：
--
作者：
CLARK, CR;GEFFEN, GM;GEFFEN, LB
本研究采用线索反应时范式，测量了正常受试者注意力的方向性投入、脱离和运动，并对脑内儿茶酚胺在内隐定向中的作用进行了测试。静脉给予氟哌利多和可乐定以抑制中枢多巴胺和去甲肾上腺素的传递。这两种药物产生的无效提示的成本降低，而有效提示的好处没有改变，这表明去甲肾上腺素和多巴胺都参与促进注意力的脱离。这些结果是相关的缓慢脱离观察到的顶叶病变在猴子和人类，因为这一地区的皮层与视觉空间分析接收密集的神经支配的多巴胺和去甲肾上腺素的预测在灵长类动物。
The role of brain catecholamines in covert orienting was tested in normal subjects using a cued reaction time paradigm which measures the directional engagement, disengagement and movement of attention. Droperidol and clonidine were administered intravenously to suppress central dopamine and noradrenaline transmission. Both drugs produced reductions in the cost of invalid cueing without change in the benefit of valid cueing suggesting that both noradrenaline and dopamine are involved in facilitating the disengagement of attention. These results are relevant to the slowed disengagement observed with parietal lesions in monkeys and humans since this region of the cortex associated with visuospatial analysis receives a dense innervation by both dopamine and noradrenaline projections in primates.