An azide and acetylene free synthesis of 1-substituted 1,2,3-triazoles
An azide and acetylene free synthesis of 1-substituted 1,2,3-triazoles
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DOI：
10.1016/j.tetlet.2020.152483
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发表时间：
2020-11-05
影响因子：
1.8
通讯作者：
Tomkinson, Nicholas C. O.
中科院分区：
文献类型：
--
作者：
Patterson, Sarah J. M.;Clark, Peter R.;Tomkinson, Nicholas C. O.
This paper details a simple and efficient 3-component synthesis of 1-substituted 1,2,3-triazoles using a primary amine, 2,2-dimethoxyacetaldehyde and tosylhydrazide. The reaction proceeds in good to excellent yields using either aliphatic or aromatic amine substrates and is tolerant of a wide range of functional groups including electron-rich and deficient aryl groups, terminal alkynes, ketones and highly sterically encumbered amines. (C) 2020 Elsevier Ltd. All rights reserved.
