Sarcopenia is negatively associated with long-term outcomes in locally advanced rectal cancer.
Sarcopenia is negatively associated with long-term outcomes in locally advanced rectal cancer.
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DOI：
10.1002/jcsm.12234
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发表时间：
2018-03
期刊：
影响因子：
--
通讯作者：
Won DD
中科院分区：
文献类型：
--
作者：
Choi MH;Oh SN;Lee IK;Oh ST;Won DD
对于局部晚期直肠癌，肌肉减少症和内脏肥胖与治疗结果的关系尚不清楚。本研究评估了骨骼肌和内脏脂肪对接受新辅助放化疗治疗后行根治性切除术的局部晚期直肠癌患者的短期和长期结局的影响。2009年1月至2013年12月期间，共纳入188例局部晚期癌症患者。新辅助放化疗后进行根治性切除。通过测量第三腰椎水平的肌肉和内脏脂肪面积，在初始分期CT中确定肌肉减少和内脏肥胖。在纳入的188例患者中，74例（39.4%）患者为肌肉减少症，97例（51.6%）患者为内脏性肥胖。在考克斯回归多变量分析中，肌肉减少和术前高水平癌胚抗原是总生存率的重要预后因素（P = 0.013，0.014，分别）。内脏肥胖与总生存期无关;然而，它确实倾向于缩短无病生存期（P = 0.079）。肌肉减少症与接受新辅助放化疗和根治性切除术的局部晚期直肠癌患者的总生存率呈负相关。内脏肥胖倾向于缩短无病生存期。未来的研究应根据身体成分状况优化患者状况。
The association of sarcopenia and visceral obesity to treatment outcome is not clear for locally advanced rectal cancer. This study evaluates the influence of skeletal muscle and visceral fat on short‐term and long‐term outcomes in locally advanced rectal cancer patients treated with neoadjuvant chemoradiation therapy followed by curative resection. A total of 188 patients with locally advanced cancer were included between January 2009 and December 2013. Neoadjuvant chemoradiotherapy was followed by curative resection. Sarcopenia and visceral obesity were identified in initial staging CT by measuring the muscle and visceral fat area at the third lumbar vertebra level. Among the 188 included patients, 74 (39.4%) patients were sarcopenic and 97 (51.6%) patients were viscerally obese. Sarcopenia and high levels of preoperative carcinoembryonic antigen were significant prognostic factors for overall survival (P = 0.013, 0.014, respectively) in the Cox regression multivariate analysis. Visceral obesity was not associated with overall survival; however, it did tend to shorten disease‐free survival (P = 0.079). Sarcopenia is negatively associated with overall survival in locally advanced rectal cancer patients who underwent neoadjuvant chemoradiation therapy and curative resection. Visceral obesity tended to shorten disease‐free survival. Future studies should be directed to optimize patient conditions according to body composition status.
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影响因子：
3.7
作者：
Gold L;Ayers D;Bertino J;Bock C;Bock A;Brody EN;Carter J;Dalby AB;Eaton BE;Fitzwater T;Flather D;Forbes A;Foreman T;Fowler C;Gawande B;Goss M;Gunn M;Gupta S;Halladay D;Heil J;Heilig J;Hicke B;Husar G;Janjic N;Jarvis T;Jennings S;Katilius E;Keeney TR;Kim N;Koch TH;Kraemer S;Kroiss L;Le N;Levine D;Lindsey W;Lollo B;Mayfield W;Mehan M;Mehler R;Nelson SK;Nelson M;Nieuwlandt D;Nikrad M;Ochsner U;Ostroff RM;Otis M;Parker T;Pietrasiewicz S;Resnicow DI;Rohloff J;Sanders G;Sattin S;Schneider D;Singer B;Stanton M;Sterkel A;Stewart A;Stratford S;Vaught JD;Vrkljan M;Walker JJ;Watrobka M;Waugh S;Weiss A;Wilcox SK;Wolfson A;Wolk SK;Zhang C;Zichi D
通讯作者：
Zichi D
DOI：
10.1016/j.jamda.2016.09.015
发表时间：
2017-03-01
影响因子：
7.6
作者：
Feng, Liang;Nyunt, Ma Shwe Zin;Ng, Tze-Pin
通讯作者：
Ng, Tze-Pin
影响因子：
4.1
作者：
Ahuja, Rajiv;Yamman, Raghunatha;Seetharam, Bellur
通讯作者：
Seetharam, Bellur
影响因子：
30.8
作者：
Aminoff, M;Carter, JE;Krahe, R
通讯作者：
Krahe, R
影响因子：
6.2
作者：
Dhonukshe-Rutten, RAM;Pluijm, SMF;van Staveren, W
通讯作者：
van Staveren, W