Apoptosis and expression of heme oxygenase-1 in heart transplant recipients during acute rejection episode
Apoptosis and expression of heme oxygenase-1 in heart transplant recipients during acute rejection episode
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DOI：
10.1016/s0041-1345(02)03526-1
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发表时间：
2002-11-01
影响因子：
0.9
通讯作者：
Gandjbakhch, I
中科院分区：
文献类型：
--
作者：
Chok, R;Sénéchal, M;Gandjbakhch, I
材料与方法本研究包括1998年12月至1999年12月在我院接受心脏移植手术的18例患者，其中男15例，女3例，平均年龄51岁。供体的平均年龄为38岁。所有患者均接受兔抗胸腺细胞球蛋白诱导治疗。给予环孢霉素、泼尼松和依穆兰维持免疫抑制。术后根据肾功能调整环孢素的剂量。研究了每例患者的两份活检标本，共36份活检标本。在9名患者中，第一次活检是在移植后第一周进行的，然后在2个月后进行第二次活检。对于其他9例患者，选择的活检发生在急性排斥反应期间;第二次活检选择在排斥反应期后。根据国际心肺移植学会标准化的标准，使用光学显微镜进行急性排斥反应发作的诊断和分级; 5例活检显示IA级排斥反应，3例显示IB级排斥反应。
MATERIALS AND METHODSThis study includes 18 heart transplant patients operated at our institution between December 1998 and December 1999,(namely 15 men, 3 women, mean age 51 years). The mean donor age was 38 years. All patients received rabbit anti-thymocyte globulin as induction therapy. Cyclosporine, prednisone, and imuran were given for maintenance immunosuppression. Cyclosporine was initiated after the operation with the dose being adjusted according to renal function. Two biopsies specimens per patient were studied for a total of 36 biopsies. In nine patients the first biopsy was done during the first post transplant week followed by a second biopsy 2 months later. For the other nine patients, the biopsy that was selected occured during an episode of acute rejection; a second biopsy was chosen after the rejection period. The diagnosis and grading of acute rejection episodes was performed using light microscopy according to the criteria standardized by the International Society of Heart and Lung Transplantation; five biopsies showed grade IA rejection and three, grade IB rejection.