EXACTLY WHAT DOES THE HAMILTON DEPRESSION RATING-SCALE MEASURE
EXACTLY WHAT DOES THE HAMILTON DEPRESSION RATING-SCALE MEASURE
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DOI：
10.1016/0022-3956(93)90037-3
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发表时间：
1993-07-01
影响因子：
4.8
通讯作者：
KUPFER, DJ
中科院分区：
文献类型：
--
作者：
GIBBONS, RD;CLARK, DC;KUPFER, DJ
本研究的目的是通过“内部构念效度”评估对汉密尔顿抑郁评定量表（HDRS）心理测量特性的实证批评。从370名符合重度抑郁症研究诊断标准的患者中获得了HDRS的个体症状反应。采用多维标准项目反应理论（IRT）模型对HDRS的维度进行评估，估计相应的项目参数，并将其表示为因子负荷和项目阈值。分析得出了一个五维解。第一个维度（抑郁情绪、内疚、自杀、工作和兴趣、躁动、精神焦虑、躯体焦虑和性欲丧失）似乎定义了全球抑郁症的严重程度。这些结果与其他已发表的因子分析研究一致，并进一步证明HDRS总分是抑郁综合征严重程度的弱指标。这些发现提供了一个基准，可以判断未来结果的充分性，因为多维IRT模型不受传统因素分析方法应用于离散症状评分时出现的统计限制。
The purpose of this study is to evaluate empirical criticism of the psychometric properties of the Hamilton Depression Rating Scale (HDRS) by undertaking an ''internal construct validity'' evaluation. Individual symptom responses for the HDRS were obtained from 370 patients meeting Research Diagnostic Criteria for major depression. A multidimensional normal item response theory (IRT) model was used to assess the dimensionality of the HDRS and estimate corresponding item parameters which were then expressed as factor loadings and item thresholds. The analysis yielded a five-dimensional solution. The first dimension (depressed mood, guilt, suicide, work and interests, agitation, psychic anxiety, somatic anxiety, and loss of libido) appeared to define global depression severity. These results are consistent with other published factor analytic studies and provide further justification for thinking that the HDRS total score is a weak index of depressive syndrome severity. The findings provide a benchmark by which the adequacy of future results may be judged, bcause the multidimensional IRT model does not suffer from the statistical limitations that arise when applying traditional factor analytic methods to discrete symptom ratings.