n-3 Docosapentaenoic Acid Intake and Relationship with Plasma Long-Chain n-3 Fatty Acid Concentrations in the United States: NHANES 2003-2014.
n-3 Docosapentaenoic Acid Intake and Relationship with Plasma Long-Chain n-3 Fatty Acid Concentrations in the United States: NHANES 2003-2014.
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DOI：
10.1002/lipd.12146
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发表时间：
2019-04
期刊：
影响因子：
1.9
通讯作者：
Chesney K Richter;K. S. Bisselou;T. Nordgren;Lynette M. Smith;A. Appiah;Nicholas A Hein;A. Anderson-Berry;P. Kris-Etherton;C. Hanson;Ann C Skulas-Ray
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作者：
Chesney K Richter;K. S. Bisselou;T. Nordgren;Lynette M. Smith;A. Appiah;Nicholas A Hein;A. Anderson-Berry;P. Kris-Etherton;C. Hanson;Ann C Skulas-Ray
长链n-3脂肪酸，二十碳五烯酸（EPA）和二十二碳六烯酸（DHA），对健康起着至关重要的作用，但之前的国家健康与营养调查（NHANES）分析表明，EPA和DHA的摄入量在美国远远低于建议（~250-500毫克/天EPA + DHA）。对二十二碳五烯酸（DPA）， EPA和DHA的代谢中间体知之甚少；然而，有证据表明DPA可能是长链n-3脂肪酸摄入的重要贡献者，并具有独特的益处。我们使用NHANES 2003-2014数据（n = 45347）来评估DPA摄入量和血浆浓度，以及EPA、DPA和DHA摄入量与血浆浓度之间的关系。2013 - 2014年平均DPA摄入量为22.3±0.8 mg/d，随着时间的推移显著增加（p < 0.001）， 2003 - 2004年最低（16.2±1.2 mg/d）。与年轻人相比，成年人（20-55岁）和老年人（55岁以上）的DPA摄入量更高。在回归分析中，DPA摄入量是血浆EPA （β = 138.5, p < 0.001）和DHA （β = 318.9, p < 0.001）的显著预测因子。血浆DPA与EPA和DHA摄入量有关（β = 13.15, p = 0.001和β = 7.4, p = 0.002），与膳食DPA无关（p = 0.3）。这表明DPA摄入量不是血浆DPA状态的良好标志（反之亦然），需要进一步研究以了解影响EPA和DPA相互转化的因素。这些发现对未来长链n-3脂肪酸的饮食建议具有启示意义。
The long-chain n-3 fatty acids, eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), play a crucial role in health, but previous National Health and Nutrition Examination Survey (NHANES) analyses have shown that EPA and DHA intake in the United States is far below recommendations (~250-500 mg/day EPA + DHA). Less is known about docosapentaenoic acid (DPA), the metabolic intermediate of EPA and DHA; however, evidence suggests DPA may be an important contributor to long-chain n-3 fatty acid intake and impart unique benefits. We used NHANES 2003-2014 data (n = 45,347) to assess DPA intake and plasma concentrations, as well as the relationship between intake and plasma concentrations of EPA, DPA, and DHA. Mean DPA intake was 22.3 ± 0.8 mg/day from 2013 to 2014, and increased significantly over time (p < 0.001), with the lowest values from 2003 to 2004 (16.2 ± 1.2 mg/day). DPA intake was higher in adults (20-55 years) and seniors (55+ years) compared to younger individuals. In regression analyses, DPA intake was a significant predictor of plasma EPA (β = 138.5; p < 0.001) and DHA (β = 318.9; p < 0.001). Plasma DPA was predicted by EPA and DHA intake (β = 13.15; p = 0.001 and β = 7.4; p = 0.002), but not dietary DPA (p = 0.3). This indicates that DPA intake is not a good marker of plasma DPA status (or vice versa), and further research is needed to understand the factors that affect the interconversion of EPA and DPA. These findings have implications for future long-chain n-3 fatty acids dietary recommendations.