Metabolic regulation of endothelial senescence.
Metabolic regulation of endothelial senescence.
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DOI：
10.3389/fcvm.2023.1232681
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发表时间：
2023
影响因子：
3.6
通讯作者：
Le, Nhat-Tu
中科院分区：
文献类型：
--
作者：
Le, Nhat-Tu
内皮细胞（EC）衰老越来越被认为是导致血管功能障碍和与年龄相关的病症和疾病（包括癌症和心血管疾病（CVD））发展的重要因素。已知细胞衰老的调节受到细胞代谢的影响。虽然人们对癌细胞和成纤维细胞等其他细胞衰老的代谢调节进行了广泛的研究，但我们对内皮细胞衰老的代谢调节的了解仍然有限。导致 EC 衰老的具体代谢变化尚未完全阐明。本综述的目的是概述细胞代谢与衰老之间复杂的相互作用，特别强调在理解细胞衰老之前的代谢变化方面的最新进展。我将总结目前关于内皮细胞衰老代谢调控的知识，旨在为潜在机制和未来研究方向提供见解。
Endothelial cell (EC) senescence is increasingly recognized as a significant contributor to the development of vascular dysfunction and age-related disorders and diseases, including cancer and cardiovascular diseases (CVD). The regulation of cellular senescence is known to be influenced by cellular metabolism. While extensive research has been conducted on the metabolic regulation of senescence in other cells such as cancer cells and fibroblasts, our understanding of the metabolic regulation of EC senescence remains limited. The specific metabolic changes that drive EC senescence are yet to be fully elucidated. The objective of this review is to provide an overview of the intricate interplay between cellular metabolism and senescence, with a particular emphasis on recent advancements in understanding the metabolic changes preceding cellular senescence. I will summarize the current knowledge on the metabolic regulation of EC senescence, aiming to offer insights into the underlying mechanisms and future research directions.
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影响因子：
20.1
作者：
Benetos A;Toupance S;Gautier S;Labat C;Kimura M;Rossi PM;Settembre N;Hubert J;Frimat L;Bertrand B;Boufi M;Flecher X;Sadoul N;Eschwege P;Kessler M;Tzanetakou IP;Doulamis IP;Konstantopoulos P;Tzani A;Korou M;Gkogkos A;Perreas K;Menenakos E;Samanidis G;Vasiloglou-Gkanis M;Kark JD;Malikov S;Verhulst S;Aviv A
通讯作者：
Aviv A
影响因子：
3.6
作者：
Banerjee, Priyanka;Rosales, Julia Enterria;Chau, Khanh;Nguyen, Minh T. H.;Kotla, Sivareddy;Lin, Steven H.;Deswal, Anita;Dantzer, Robert;Olmsted-Davis, Elizabeth A.;Nguyen, Hung;Wang, Guangyu;Cooke, John P.;Abe, Jun-ichi;Le, Nhat-Tu
通讯作者：
Le, Nhat-Tu
影响因子：
48
作者：
Biancalani T;Scalia G;Buffoni L;Avasthi R;Lu Z;Sanger A;Tokcan N;Vanderburg CR;Segerstolpe Å;Zhang M;Avraham-Davidi I;Vickovic S;Nitzan M;Ma S;Subramanian A;Lipinski M;Buenrostro J;Brown NB;Fanelli D;Zhuang X;Macosko EZ;Regev A
通讯作者：
Regev A
影响因子：
2.1
作者：
Aird KM;Zhang R
通讯作者：
Zhang R
DOI：
10.20517/jca.2022.13
发表时间：
2022-01-01
期刊：
The journal of cardiovascular aging
影响因子：
--
作者：
Banerjee, Priyanka;Olmsted-Davis, Elizabeth A;Abe, Jun-Ichi
通讯作者：
Abe, Jun-Ichi