In vivo kinematical validated knee model for preclinical testing of total knee replacement
In vivo kinematical validated knee model for preclinical testing of total knee replacement
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DOI：
10.1016/j.compbiomed.2021.104311
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发表时间：
2021-03
影响因子：
7.7
通讯作者：
Liming Shu;Jiang Yao;Ko Yamamoto;Takashi Sato;N. Sugita
中科院分区：
文献类型：
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作者：
Liming Shu;Jiang Yao;Ko Yamamoto;Takashi Sato;N. Sugita
背景和目的计算膝关节模型有助于在各种动态载荷下进行有效的组件设计评估和临床前测试。然而，开发具有指定韧带约束的高度模仿的动态全膝关节模型，通过体内实验提供高预测精度仍然是一个挑战。方法在本研究中，开发了一种肌肉骨骼集成力驱动的显式有限元膝关节模型，其中胫股关节和髌股关节受到详细软组织的约束。同时将比例积分微分控制器添加到拐点模型中以跟踪边界条件。通过特定受试者的肌肉骨骼模型预测股四头肌和腘绳肌的动作，并与肌电图结果进行匹配。结果与步态周期中的体内透视结果相比，胫股关节运动学的预测结果在趋势和幅度方面表现出一致（前后平移：RMSE= 1.1 mm，r2= 0.87；下-上平移：RMSE= 0.83 mm，r2= 0.84；内侧-外侧平移：RMSE= 0.82 mm，r2= 0.05；屈伸旋转：RMSE= 0.23°，r2= 1；内-外旋转：RMSE= 1.85°，r2= 0.65；旋转：RMSE= 1.39°，r2= 0.08）。在胫股关节和髌股关节上同步模拟了接触力学，包括接触面积、压力和应力。结论该研究提供了校准的膝关节模型和运动学验证方法，可广泛用于临床前测试和膝关节假体设计。
Background and objectiveA computational knee model facilitates efficient component design evaluations and preclinical testing under various dynamic loadings. However, the development of a highly mimicked dynamic whole knee model with specified ligament constraints that provides high predictive accuracy with in-vivo experiments remains a challenge.MethodsIn the present study, a musculoskeletal integrated force-driven explicit finite-element knee model with tibiofemoral and patellofemoral joints constrained with detailed soft tissue was developed. A proportional-integral-derivative controller was concurrently added to the knee model to track the boundary conditions. The actuations of the quadriceps and hamstrings were predicted via a subject-specific musculoskeletal model and matched with electromyography results.ResultsCompared to in-vivo fluoroscopic results in a gait cycle, the predicted results of the kinematics of the tibiofemoral joint exhibited an agreement in terms of tendency and magnitude (anterior–posterior translation:RMSE= 1.1 mm,r2= 0.87; inferior–superior translation:RMSE= 0.83 mm,r2= 0.84; medial–lateral translation:RMSE= 0.82 mm,r2= 0.05; flexion–extension rotation:RMSE= 0.23°,r2= 1; internal-external rotation:RMSE= 1.85°,r2= 0.65; varus–valgus rotation:RMSE= 1.39°,r2= 0.08). Contact mechanics, including the contact area, pressure, and stress, were synchronously simulated on the tibiofemoral and patellofemoral joints.ConclusionsThe study provides a calibrated knee model and a kinematical validation approach that can be widely used in preclinical testing and knee prosthesis design.