Sex-specific alterations in preterm brain
Sex-specific alterations in preterm brain
复制标题
DOI：
10.1038/s41390-018-0187-5
复制
发表时间：
2019-01-01
影响因子：
3.6
通讯作者：
Nopoulos, Peg
中科院分区：
文献类型：
--
作者：
Benavides, Amanda;Metzger, Andrew;Nopoulos, Peg
背景：关于早产儿脑成像的文献大多是由评估新生儿的研究组成的，然而大脑发育最活跃的时期是从出生到1岁。这项研究旨在通过对12个月大的早产儿进行磁共振成像扫描，获得定量的大脑测量结果。方法：受试者组被设计捕获胎龄（GA）从早产儿到足月婴儿的广泛范围。一个特定年龄的图谱产生了定量的大脑测量。使用回归模型预测遗传和性别对大脑测量的影响。结果：性别对颅内容积有主要影响：(1)男性比女性大；(2)大脑皮层灰质比例（女性>男性），(3)大脑白质比例（男性>女性）。遗传算法预测脑容量和脑脊髓液。GA还以性别特异性的方式预测皮质灰质，GA对男性皮质体积有显著影响，但对女性没有影响。结论及相关性：大脑结构的性别差异在生命早期很大。GA具有性别特异性效应，突出了评估早产儿神经发育结局中性别效应的重要性。
BACKGROUND: The literature on brain imaging in premature infants is mostly made up of studies that evaluate neonates, yet the most dynamic time of brain development happens from birth to 1 year of age. This study was designed to obtain quantitative brain measures from magnetic resonance imaging scans of infants born prematurely at 12 months of age.METHODS: The subject group was designed to capture a wide range of gestational age (GA) from premature to full-term infants. An age-specific atlas generated quantitative brain measures. A regression model was used to predict effects of GA and sex on brain measures.RESULTS: There was a primary effect of sex on: (1) intracranial volume, males> females; (2) proportional cerebral cortical gray matter (females > males), and (3) cerebral white matter (males > females). GA predicted cerebral volume and cerebral spinal fluid. GA also predicted cortical gray matter in a sex-specific manner with GA having a significant effect on cortical volume in the males, but not in females.CONCLUSIONS AND RELEVANCE: Sex differences in brain structure are large early in life. GA had sex-specific effects highlighting the importance evaluating sex effects in neurodevelopmental outcomes of premature infants.