Tau overexpression impairs neuronal endocytosis by decreasing the GTPase dynamin 1 through the miR-132/MeCP2 pathway
Tau overexpression impairs neuronal endocytosis by decreasing the GTPase dynamin 1 through the miR-132/MeCP2 pathway
复制标题
Tau 过度表达通过 miR-132/MeCP2 途径减少 GTPase dynamin 1 损害神经元内吞作用
DOI：
10.1111/acel.12929
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发表时间：
2019
期刊：
影响因子：
7.8
通讯作者：
Zhu Ling Qiang
中科院分区：
文献类型：
--
作者：
Xie Ao Ji;Hou Tong Yao;Xiong Wan;Huang He Zhou;Zheng Jie;Li Ke;Man Heng Ye;Hu Ya Zhuo;Han Zhi Tao;Zhang Hong Hong;Wei Na;Wang Jian Zhi;Liu Dan;Lu Youming;Zhu Ling Qiang
Tauopathies are a class of neurodegenerative diseases that are characterized by pathological aggregation of tau protein, which is accompanied by synaptic disorders. However, the role of tau in endocytosis, a fundamental process in synaptic transmission, remains elusive. Here, we report that forced expression of human tau (hTau) in mouse cortical neurons impairs endocytosis by decreasing the level of the GTPase dynamin 1viadisruption of the miR‐132‐MeCP2 pathway; this process can also be detected in the brains of Alzheimer's patients and hTau mice. Our results provide evidence for a novel role of tau in the regulation of presynaptic function.
