Modeling Transient Pupillary Light Reflex Induced by a Short Light Flash
Modeling Transient Pupillary Light Reflex Induced by a Short Light Flash
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DOI：
10.1109/tbme.2010.2080678
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发表时间：
2011-01-01
影响因子：
4.6
通讯作者：
Yao, Gang
中科院分区：
文献类型：
--
作者：
Fan, Xiaofei;Yao, Gang
本文提出了一个瞳孔对光反射模型，该模型考虑了虹膜肌肉的力学特性以及来自副交感神经和交感神经系统的调制输入。该模型能很好地描述不同强度的短闪光引起的实验PLR响应。此外，一个逆的方法来拟合这个模型的数值实验PLR数据。该模型在实验性人体PLR数据中进行了测试，以分别提取PLR期间的副交感神经和交感神经调制。结果表明，女性的副交感神经活性高于男性，而交感神经活性低于男性，这与以往心血管研究的结果一致。这个新的模型可能有助于提高我们的理解PLR过程中，并可应用于分析自主神经的相互作用瞳孔反应。
A pupillary light reflex (PLR) model was proposed in this paper by considering the iris muscle mechanical properties and modulation inputs from both parasympathetic and sympathetic systems. The model can describe very well the experimental PLR responses induced by a short light flash of various intensities. In addition, an inverse method was developed to fit numerically this model to experimental PLR data. The model was tested in experimental human PLR data to extract separately the parasympathetic and sympathetic modulations during PLR. The results indicated a higher parasympathetic and a lower sympathetic activity in females than in males, which was consistent with previous findings in cardiovascular studies. This new model may help improve our understanding of the PLR process and could be applied to analyze autonomic nervous interaction during pupillary responses.