Uterotropic 6-methoxybenzoxazolinone is an adrenergic agonist and a melatonin analog.
Uterotropic 6-methoxybenzoxazolinone is an adrenergic agonist and a melatonin analog.
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Uterotropic 6-甲氧基苯并恶唑啉酮是一种肾上腺素能激动剂和褪黑激素类似物。
DOI：
10.1016/0303-7207(88)90042-1
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发表时间：
1988
影响因子：
4.1
通讯作者：
Berger,PJ
中科院分区：
文献类型：
--
作者：
Sweat,FW;Berger,PJ
6-甲氧基苯并恶唑啉酮（MBOA）是一种从禾本科植物中分离出来的化合物，对多种动物具有促性腺作用。MBOA的弱β-肾上腺素能激动剂特性通过其在体外刺激来自几种组织的腺苷酸环化酶而显示。与子宫颗粒部分特异性结合的氚化MBOA也被α-和β-肾上腺素能化合物取代。MBOA的肾上腺素能特性表明它可能发挥多种作用，包括直接作用于促性腺激素的合成和释放。混合肾上腺素能激动剂麻黄碱和抗抑郁剂丙咪嗪也被发现是向子宫的田鼠montanus以下注射协议与MBOA使用。MBOA在结构上类似于褪黑激素（5-甲氧基-N-乙酰色胺）; [3 H]褪黑激素与子宫和松果体膜结合，被MBOA和其他肾上腺素能药物取代。MBOA是β-肾上腺素能激动剂和褪黑激素类似物的事实可以解释该化合物对性发育的刺激和抑制作用。
6-Methoxybenzoxazolinone (MBOA) is a compound isolated from grasses which has gonadotropic effects in a variety of animals. The weak β-adrenergic agonist character of MBOA is shown by its in vitro stimulation of adenylate cyclase from several tissues. Tritiated MBOA bound specifically to particulate fractions from uterus is also displaced by α- and β-adrenergic compounds. The adrenergic properties of MBOA suggest it may exert diverse effects including direct actions on gonadotropin synthesis and release. The mixed adrenergic agonist ephedrine and the antidepressant imipramine were also found to be Uterotropic in the voleMicrotus montanusfollowing injection protocols used with MBOA. MBOA is structurally similar to melatonin (5-methoxy-N-acetyltryptamine); [3H]melatonin which binds to uterine and pineal membranes is displaced by MBOA and by other adrenergic agents. The fact that MBOA is a β-adrenergic agonist and a melatonin analog can account for stimulatory and inhibitory effects of this compound on sexual development.