The prediction of resting energy expenditure in type 2 diabetes mellitus is improved by factoring for glycemia
The prediction of resting energy expenditure in type 2 diabetes mellitus is improved by factoring for glycemia
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DOI：
10.1038/sj.ijo.0802178
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发表时间：
2002-12-01
影响因子：
4.9
通讯作者：
Venuta, T
中科院分区：
文献类型：
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作者：
Gougeon, R;Lamarche, M;Venuta, T
背景：据报道，预测方程高估了肥胖者的静息能量消耗(REE)。在肥胖的2型糖尿病患者中，高血糖的存在导致REE升高，其对这些方程的有效性的影响尚不清楚。目的：我们测试(1)糖尿病控制指标是否与2型糖尿病的REE独立相关，以及(2)它们是否会改善预测方程。设计：一项针对65名(男性25名，女性40名)肥胖的2型糖尿病受试者的横断面研究。测量的变量是：通风罩间接量热法测量的REE，生物阻抗分析的身体成分，体围，空腹血糖(FPG)和血红蛋白A(1c)。结果：校正体重、脱脂质量、年龄和性别后的REE，以空腹血糖、脱脂体重、年龄和性别为标准，与空腹血糖、糖化血红蛋白呈正相关(P=0.017)，与空腹血糖(P=0.013)和糖化血红蛋白(1c)呈正相关(P=0.013)。体重是稀土元素的主要决定因素。与臀围和空腹血糖一起，它可以解释81%的变异。FPG将方程的可预测性提高了3%。如果血糖控制不佳，则表示REE增加高达8%。结论：我们的数据表明，在肥胖的2型糖尿病受试者中，将空腹血糖作为一个变量时，REE更好地预测。
BACKGROUND: Predictive equations have been reported to overestimate resting energy expenditure (REE) for obese persons. The presence of hyperglycemia results in elevated REE in obese persons with type 2 diabetes, and its effect on the validity of these equations is unknown.OBJECTIVE: We tested whether (1) indicators of diabetes control were independent associates of REE in type 2 diabetes and (2) their inclusion would improve predictive equations.DESIGN: A cross-sectional study of 65 (25 men, 40 women) obese type 2 diabetic subjects. Variables measured were: REE by ventilated-hood indirect calorimetry, body composition by bioimpedance analysis, body circumferences, fasting plasma glucose (FPG) and hemoglobin A(1c). Data were analyzed using stepwise multiple linear regression.RESULTS: REE, corrected for weight, fat-free mass, age and gender, was significantly greater with FPG > 10 mmol/l (P = 0.017) and correlated with FPG (P = 0.013) and hemoglobin A(1c) as percentage upper limit of normal (P = 0.02). Weight was the main determinant of REE. Together with hip circumference and FPG, it explained 81% of the variation. FPG improved the predictability of the equation by > 3%. With poor glycemic control, it can represent an increase in REE of up to 8%.CONCLUSION: Our data indicate that in a population of obese subjects with type 2 diabetes mellitus, REE is better predicted when fasting plasma glucose is included as a variable.