Cognitive changes in the preclinical phase of familial Alzheimer's disease
Cognitive changes in the preclinical phase of familial Alzheimer's disease
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DOI：
10.1080/13803390601174151
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发表时间：
2007-11-01
影响因子：
2.2
通讯作者：
Lopera, Francisco
中科院分区：
文献类型：
--
作者：
Arango-Lasprilia, Juan Carlos;Cuetos, Fernando;Lopera, Francisco
很少有研究探讨阿尔茨海默病 (AD) 临床前阶段语言缺陷的存在。来自哥伦比亚安蒂奥基亚省的 19 名 14 号染色体 E280A 早老素 1 基因突变健康携带者和 21 名非携带者家庭成员接受了词汇语义过程的神经语言学评估。两组的年龄、教育水平和性别相似。在名人面孔命名方面，运营商的得分明显低于非运营商。在临床诊断可能的家族性 AD 之前，可以检测词汇语义任务中的认知变化，神经语言学评估也可能是散发性 AD 早期临床诊断的有用工具。
Few studies have examined the presence of linguistic deficits in the preclinical phase of Alzheimer's disease (AD). A total of 19 healthy carriers of the E280A presenilin-1 gene mutation in chromosome 14 and 21 noncarrier family members from Antioquia, Colombia, were administered a neurolinguistic evaluation of lexical-semantic processes. Both groups were similar in age, educational level, and gender. Carriers scored significantly lower than noncarriers on naming of famous faces. Cognitive changes in lexical-semantic tasks can be detected before the clinical diagnosis of probable familial AD, and a neurolinguistic evaluation may be a useful tool in the early clinical diagnosis of sporadic AD as well.