CXCR3 polymorphisms associated with risk of asthma
CXCR3 polymorphisms associated with risk of asthma
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DOI：
10.1016/j.bbrc.2005.07.019
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发表时间：
2005-09-09
影响因子：
3.1
通讯作者：
Oh, B
中科院分区：
文献类型：
--
作者：
Cheong, HS;Park, CS;Oh, B
已知染色体 Xq13 上的趋化因子（C-X-C 基序）受体 3 (CXCR3) 基因在炎症和免疫反应中发挥关键作用。为了发现与哮喘有关的多态性，我们研究了 CXCR3 的遗传多态性，以评估其作为哮喘宿主遗传学研究的潜在候选基因。统计分析显示，内含子1中的一个SNP（c.12+2346>A）与哮喘发生风险显着相关（P=0.007，OR=0.81）。通过按性别和特应性状态分层的亚组分析，c的遗传效应。 12+2346 > A 对哮喘的影响在男性特应性受试者中更为明显（P = 0.0009，OR = 0.61）。我们的研究结果表明，CXCR3 的多态性可能是哮喘发生风险的遗传因素之一，尤其是在男性特应性受试者中。本研究中确定的 CXCR3 变异/单倍型信息将为控制哮喘及其亚组特应性的策略提供有价值的信息和见解。 (c) 2005 Elsevier Inc. 保留所有权利。
The chemokine (C-X-C motif) receptor 3 (CXCR3) gene, on chromosome Xq13, is known to have critical roles in inflammatory and immune responses. In an effort to discover polymorphisms have been implicated in asthma, we investigated the genetic polymorphisms in CXCR3 to evaluate it as a potential candidate gene for a host genetic study of asthma. Statistical analysis revealed that one SNP in intron 1, c.12+2346 > A, showed significant association with the risk of asthma development (P=0.007, OR = 0.81). By subgroup analyses stratified by gender and atopic status, the genetic effect of c. 12+2346 > A on asthma was more apparent among male atopic subjects (P = 0.0009, OR = 0.61). Our findings suggest that polymorphisms in CXCR3 might be one of the genetic factors for the risk of asthma development, especially in male atopic subjects. CXCR3 variation/haplotype information identified in this study will provide valuable information and insight into strategies for the control of asthma and its subgroup, atopy. (c) 2005 Elsevier Inc. All rights reserved.