DIMINISHED CURIOSITY IN PATIENTS WITH PROBABLE ALZHEIMERS-DISEASE AS MEASURED BY EXPLORATORY EYE-MOVEMENTS
DIMINISHED CURIOSITY IN PATIENTS WITH PROBABLE ALZHEIMERS-DISEASE AS MEASURED BY EXPLORATORY EYE-MOVEMENTS
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DOI：
10.1212/wnl.42.2.320
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发表时间：
1992-02-01
期刊：
影响因子：
9.9
通讯作者：
MESULAM, MM
中科院分区：
文献类型：
--
作者：
DAFFNER, KR;SCINTO, LFM;MESULAM, MM
阿尔茨海默病 (AD) 的临床记录表明，一些患者在病程早期表现出好奇心和主动性明显下降。这种行为变化极难通过实验来测量。我们通过测量 12 名可能患有 AD 的患者和 10 名匹配的对照者对刺激性视觉刺激的探索性眼球运动来研究好奇心的一个方面。受试者观看幻灯片，每张幻灯片都包含一个不协调或不规则的图形，与一个一致或规则的图形配对。与对照组相比，他们花更多的时间观看不协调的刺激，而 AD 患者则平均分配观看时间，并且比对照组花更少的时间观看新颖的刺激。此外，当呈现包含意外元素的图片幻灯片时，AD 患者总体上表现出视觉探索能力减弱，并且对不协调部分的注意力减少。进一步的分析表明，这一结果不能用认知能力普遍下降或眼球运动或视觉注意力引导问题来充分解释。我们得出的结论是，AD 患者表现出好奇心减弱，这可以通过探索性眼球运动的研究来测量。
Clinical accounts of Alzheimer's disease (AD) suggest that some patients exhibit markedly diminished curiosity and initiative early in the course of their illness. Such behavioral changes are extremely difficult to measure experimentally. We studied one aspect of curiosity by measuring exploratory eye movements in response to provocative visual stimuli in 12 patients with probable AD and 10 matched controls. Subjects viewed slides, each of which contained an incogruous or irregular figure paired with a congruous or regular one. Unlike controls, who spent significantly more time viewing the incongruous stimuli, AD patients distributed their viewing time equally and spent significantly less time than controls looking at the novel stimuli. Additionally, when presented with picture slides containing an unexpected element, AD patients exhibited diminished visual exploration overall and decreased attention to the incongruous part. Further analyses suggest that the results cannot be adequately explained by a general decline in cognition or by problems with ocular motility or directing visual attention. We conclude that AD patients exhibit diminished curiosity which can be measured by the study of exploratory eye movements.