The role of reactive oxygen species in signalling from chloroplasts to the nucleus
The role of reactive oxygen species in signalling from chloroplasts to the nucleus
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DOI：
10.1111/j.1399-3054.2009.01331.x
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发表时间：
2010-04-01
影响因子：
6.4
通讯作者：
Mullineaux, Philip M.
中科院分区：
文献类型：
--
作者：
Galvez-Valdivieso, Gregorio;Mullineaux, Philip M.
叶绿体的功能与细胞活动的其他部分的协调需要从这个细胞器到细胞核的持续的通信流。叶绿体是产生活性氧（ROS）的主要场所，其作为分子氧（O-2）还原的副产物或其在高能量色素存在下的激发。这种ROS，虽然对细胞有潜在的损害，但也是响应于环境线索而从这些细胞器到细胞核的信号的重要引发剂或转换器。ROS可以启动这样的逆行信号通路，触发程序性细胞死亡或对变化的条件的调整。这种不同的结果有影响的方式，其中ROS的信号转导完成，是本次审查的主题。在应对轻度应激的情况下，由于其反应性或由于其遏制细胞的抗氧化系统，有人提出，活性氧从事或启动信号在或非常接近其生产的网站。相比之下，在更极端的条件下，ROS被提议扩散远离其生产位点，从而引发一组不同的信号事件。
The coordination of chloroplast function with the rest of cellular activity requires a continual stream of communication from this organelle to the nucleus. Chloroplasts are major sites of the production of reactive oxygen species (ROS) as either by-products of the reduction of molecular oxygen (O-2) or its excitation in the presence of highly energised pigments. Such ROS, while potentially damaging to the cell, are also important initiators or transducers of signals from these organelles to the nucleus in response to environmental cues. ROS can initiate such retrograde signalling pathways that trigger either programmed cell death or adjustment to changed conditions. Such different outcomes have implications for the way in which signal transduction by ROS is accomplished and is the subject of this review. In response to mild-stress situations, and as a consequence of their reactivity or because of their containment by cellular antioxidant systems, it is proposed that ROS engage with or initiate signalling at or very near their site of production. In contrast, under more extreme conditions, ROS are proposed to diffuse away from their site of production and consequently elicit a different set of signalling events.