Phosphorus levels are associated with subclinical atherosclerosis in the general population
Phosphorus levels are associated with subclinical atherosclerosis in the general population
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DOI：
10.1016/j.atherosclerosis.2007.11.004
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发表时间：
2008-08-01
期刊：
影响因子：
5.3
通讯作者：
Raggi, Paolo
中科院分区：
文献类型：
--
作者：
Onufrak, Stephen J.;Bellasi, Antonio;Raggi, Paolo
背景：在一项针对普通人群的研究中，血磷升高与肾功能衰竭患者的死亡率有关。方法：对13.340名45-年龄在社区动脉粥样硬化风险研究中未发现冠心病、中风或肾脏疾病的受试者，测定血磷水平与颈动脉内膜中层厚度的关系。结果：血磷水平与年龄、女性、糖尿病、高血压、高胆固醇血症和纤维蛋白原水平显著相关(P<0.05)。
Background: Elevated serum phosphorus has been linked to mortality among patients with renal failure and in one study in the general population. The aim of our study was to examine the association of serum phosphorus level with carotid atherosclerosis in the general population.Methods: We determined the association of serum phosphorus levels with carotid intima-media thickness (cIMT) in 13.340 subjects 45-64 years old without known coronary heart disease, stroke, or renal disease from the Atherosclerosis Risk in Communities (ARIC) study.Results: Phosphorus levels were significantly associated with age, female gender, diabetes mellitus, hypertension, hypercholesterolemia and fibrinogen levels (p