A distinct infection cost associated with trans-generational priming of antibacterial immunity in bumble-bees
A distinct infection cost associated with trans-generational priming of antibacterial immunity in bumble-bees
复制标题
DOI：
10.1098/rsbl.2009.0458
复制
发表时间：
2009-12-23
期刊：
影响因子：
3.3
通讯作者：
Schmid-Hempel, Paul
中科院分区：
文献类型：
--
作者：
Sadd, Ben M.;Schmid-Hempel, Paul
母体对子代免疫的兼性调节或跨代免疫启动的适应价值将取决于生态背景。特别是，在免疫调节和后代环境之间存在不匹配的情况下，由于存在相关成本，母亲和后代之间的免疫联系可能是不利的。个人应对免疫挑战的成本被广泛记录在案。然而，除了父母，跨代免疫启动的相关成本也与后代有关，但目前还不清楚后代将承担什么成本。在大黄蜂中，当母亲在蜂群建立之前接受基于细菌的免疫挑战时，更高的抗菌活性被证明是一种跨代效应。在这里，我们表明，尽管来自免疫挑战母亲的幼稚后代没有证据表明与能量相关的直接生存成本，但他们确实显示出对一种明显与母亲挑战无关的寄生虫的易感性增加。与跨代免疫启动相关的成本的存在将根据生态环境塑造这一特征的进化。
The adaptive value of facultative maternal adjustment of offspring immunity, or trans-generational immune-priming, will depend on the ecological background. In particular, where there is a mismatch between the immune adjustment and offspring environment, the immunological link between mothers and offspring may be disadvantageous owing to the presence of associated costs. Costs to an individual of responding to an immune challenge are extensively documented. However, in addition to parents, the relevant costs for trans-generational immune-priming also pertain to offspring, but as yet it is unknown what costs offspring will bear. In bumble-bees, higher antibacterial activity has been shown as a trans-generational effect when mothers receive a bacterial-based immune challenge prior to colony founding. Here we show that while naive offspring from immune-challenged mothers do not show evidence for a direct energy-related survival cost, they do show increased susceptibility to a parasite distinctly unrelated to the maternal challenge. The presence of costs associated with trans-generational immune-priming will shape the evolution of this trait depending on the ecological setting.