EBV LMP1 regulates cancer growth through IRF-7 in nasopharyngealcarcinoma.
EBV LMP1 regulates cancer growth through IRF-7 in nasopharyngealcarcinoma.
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DOI：
10.35841/molecular-oncology.1.1.47-52
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发表时间：
2017
影响因子：
6.6
通讯作者：
Jianguo Wu;Dongsheng Xu;Qian-ming Cheng;Luwen Zhang;Dandan Cheng;Jing Zhao-
中科院分区：
文献类型：
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作者：
Jianguo Wu;Dongsheng Xu;Qian-ming Cheng;Luwen Zhang;Dandan Cheng;Jing Zhao-
The cellular Interferon (IFN) regulatory factor-7 (IRF-7) was originally identified in cells with Epstein-Barr virus (EBV) infection, which constituted of positive circuit with viral oncoprotein latent membrane protein 1 (LMP1), and both proteins are involved in neoplasia. EBV is known to be associated with the development of various cancers, including Hodgkin lymphoma, non-Hodgkin lymphoma (NHL), Burkitt lymphoma, gastric lymphoma, and nasopharyngeal carcinoma (NPC). Although the exact role of IRF-7 in EBV-related oncogenesis is not clear, in this study, we demonstrated the role of IRF-7 in angiogenesis suppression via LMP1 down-regulation. Additionally, we employed knock down of IRF-7 and verified the inhibition of IRF-7 in NPC growth in vivo. These findings suggest that IRF-7 could be a potential therapeutic target in EBV-infected NPC tumors.
