Positron emission tomography studies in eating disorders: multireceptor brain imaging, correlates with behavior and implications for pharmacotherapy
Positron emission tomography studies in eating disorders: multireceptor brain imaging, correlates with behavior and implications for pharmacotherapy
复制标题
DOI：
10.1016/j.nucmedbio.2005.06.011
复制
发表时间：
2005-10-01
影响因子：
3.1
通讯作者：
Kaye, WH
中科院分区：
文献类型：
--
作者：
Frank, GK;Kaye, WH
现代成像技术使疾病特异性器官神经递质或蛋白质受体位置可视化，越来越能够在分子水平上定义病理过程。其中一种成像方式，正电子发射断层扫描（PET），用于评估脑神经受体结合，已经彻底改变了可能与人类行为有关的生物标志物的体内评估。这些研究可能有助于确定可能与精神病理直接相关的化学靶点，从而为药物干预提供机会。在这篇综述中，我们描述了进食障碍（EDs）的PET研究结果。饮食失调通常是一种使人衰弱的疾病，其表现形式非常相似。那些确定了特定血清素和多巴胺受体改变的研究可以将恢复的ED受试者与对照组以及ED亚组区分开来。此外，还发现了受体结合与行为结构的相关性，如避免伤害或寻求新奇。这些公认的受体现在可以帮助我们从精神病学研究和临床中的非特异性治疗方法转向更多的综合征和症状特异性治疗方法的可能性。(c) 2005爱思唯尔公司版权所有。
Modem imaging techniques that visualize disease-specific organ neurotransmitter or protein receptor sites are increasingly able to define pathological processes on a molecular level. One of those imaging modalities, positron emission tomography (PET), for the assessment of brain neuroreceptor binding has revolutionized the in vivo assessment of biologic markers that may be related to human behavior. Such studies may help identify chemical targets that may be directly related to psychiatric pathology and, thus, opportunities for pharmacological intervention. In this review, we describe results from PET studies in eating disorders (EDs). Eating disorders are frequently debilitating illnesses that are quite homogeneous in their presentation. Those studies that identified particular serotonin and dopamine receptor alterations can distinguish recovered ED subjects from controls as well as ED subgroups. Furthermore, correlations of receptor binding with behavioral constructs, such as harm avoidance or novelty seeking, could be found. These recognized receptors may now help us to move away from rather nonspecific treatment approaches in psychiatric research and clinic to the possibility of more syndrome- and symptom-specific treatment approaches. (c) 2005 Elsevier Inc. All rights reserved.