Sertraline in the treatment of major depression following mild traumatic brain injury
Sertraline in the treatment of major depression following mild traumatic brain injury
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DOI：
10.1176/appi.neuropsych.12.2.226
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发表时间：
2000-03-01
影响因子：
2.9
通讯作者：
Katon, WJ
中科院分区：
文献类型：
--
作者：
Fann, JR;Uomoto, JM;Katon, WJ
对15名轻度创伤性脑损伤后3 - 24个月诊断为重度抑郁症的患者进行了一项为期8周的舍曲林安慰剂导入试验。舍曲林治疗第8周时，汉密尔顿抑郁量表评分下降≥ 50%者13例（87%），ct评分≤ 7者10例（67%）。治疗后，患者的心理困扰、愤怒和攻击性、功能和脑震荡后症状均有显著改善。
An 8-week, nonrandomized, single-blind, placebo run-in trial Of sertraline was conducted on 15 patients diagnosed with major depression between 3 and 24 months after a mild traumatic brain injury. On the Hamilton Rating Scale for Depression, 13 (87%) han a decrease in score of greater than or equal to 50% ("response"), and 10 (67%) achieved ct score of less than or equal to 7 ("remission") by week 8 of sertraline. There was statistically significant improvement in psychological distress, anger and aggression, functioning, ann postconcussive symptoms with treatment.