Diagnostic value of breast proton magnetic resonance spectroscopy at 1.5T in different histopathological types.
Diagnostic value of breast proton magnetic resonance spectroscopy at 1.5T in different histopathological types.
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DOI：
10.1100/2012/508295
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发表时间：
2012
影响因子：
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通讯作者：
Baek HM
中科院分区：
文献类型：
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作者：
Baek HM
本研究的目的是探讨定量质子磁共振波谱(1H-MRS)对1.5T乳腺病变的诊断价值，并利用受试者工作特征(ROC)分析评价活体乳腺1H-MRS的诊断性能。112例患者(其中恶性肿瘤99例，良性肿瘤13例)接受了MRI/MRS检查。检测含胆碱化合物(Tcho)水平，并与组织学结果进行比较。99例恶性肿瘤患者中65例(66%)血清TchO水平在0.08~9.99 /kg之间。13个良性病变中，1H-MRS检出1个假阳性，Tcho水平为0.66 /kg。获得最高准确度的最佳Tcho水平界值为0.0mmo1/kg。 ；由此得出的灵敏度为66%，特异度为92%，用于区分良恶性病变。Tcho在浸润性癌中的水平高于导管原位癌或良性病变，可能与浸润性癌中更具侵袭性的行为或更快的细胞复制有关。体内定量 1H-MRS可能为乳腺癌的组织病理学分型提供有用的信息。
The purpose of this study was to investigate the usefulness of quantitative proton magnetic resonance spectroscopy (1H-MRS) for characterizing breast lesions at 1.5T, and to evaluate the diagnostic performance of in vivo breast 1H-MRS using receiver operating characteristics (ROC) analysis. 112 patients (99 malignant and 13 benign tumors) who were scanned with the MRI/MRS protocol were included in this study. Choline-containing compounds (tCho) levels were measured and compared with histological findings. The measured tCho levels in this work had range of 0.08–9.99 mmol/kg from 65 (66%) of 99 patients with malignant tumors. Of the 13 benign lesions, 1H-MRS detected one as false positive, with tCho level of 0.66 mmol/kg. The optimal tCho level cutoff point that yielded the highest accuracy was found to be >0.0 mmol/kg. The resulting sensitivity was 66% and specificity 92% for distinguishing benign from malignant lesions. The tCho levels were found to be higher in invasive cancer compared to ductal carcinoma in situ or benign lesions, possibly associated with more aggressive behavior or faster cell replication in invasive cancer. Quantitative in vivo 1H-MRS may provide useful information for characterizing histopatholoigical types in breast cancer.