Identification of the S-Endo 1 endothelial-associated antigen
Identification of the S-Endo 1 endothelial-associated antigen
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DOI：
10.1006/bbrc.1996.0037
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发表时间：
1996-01-05
影响因子：
3.1
通讯作者：
Sampol, J
中科院分区：
文献类型：
--
作者：
Bardin, N;Frances, V;Sampol, J
我们最近描述了一种单克隆抗体，S-Endo 1，识别在所有类型的人内皮细胞中组成性表达的分子。我们发现这个位于内皮细胞-细胞交界处的118 kDa左右的蛋白与MUC18的序列相同，MUC18被描述为人类黑色素瘤的肿瘤标志物。在不同细胞类型间观察到的抗体免疫反应性和抗原分子量异质性的差异强烈提示S-Endo 1抗原同工型的表达。(C) 1996学术出版社，Inc.
We have recently described a monoclonal antibody, S-Endo 1, recognizing a molecule constitutively expressed in all types of human endothelial cells. We showed that this protein around 118 kDa acid located at the endothelial cell-cell junction presented sequence identity with MUC18 described as a tumor marker in human melanoma. The difference in antibodies immunoreactivity and antigen molecular weight heterogeneity observed between various cell types strongly suggested S-Endo 1 antigen isoforms expression. (C) 1996 Academic Press, Inc.