Disseminated infection with Balamuthia mandrillaris in a dog
Disseminated infection with Balamuthia mandrillaris in a dog
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DOI：
10.1354/vp.41-5-506
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发表时间：
2004-09-01
影响因子：
2.4
通讯作者：
De Cock, H
中科院分区：
文献类型：
--
作者：
Foreman, O;Sykes, J;De Cock, H
双侧慢性肉芽肿性肾炎和脑膜脑炎的尸检诊断为2岁的雄性大丹狗。基于形态学特征、免疫组化染色和新设计引物对的脱氧核糖核酸聚合酶链反应，鉴定病原菌为Balamuthia mandrillaris。肾和脑实质内可见滋养体和囊状变形虫。这是首次报道犬感染曼氏螺旋体。
Bilateral chronic granulomatous nephritis and meningoencephalitis were diagnosed on necropsy of a 2-year-old male Great Dane dog. The causative agent was identified as Balamuthia mandrillaris, based on morphologic features, immunohistochemical staining, and deoxyribonucleic acid detection using the polymerase chain reaction with newly designed primer pairs. Trophozoite and cystic forms of the amoeba were evident within the kidneys and brain parenchyma. This is the first report on a B. mandrillaris infection in a dog.