Advances in arterial spin labelling MRI methods for measuring perfusion and collateral flow.
Advances in arterial spin labelling MRI methods for measuring perfusion and collateral flow.
复制标题
DOI：
10.1177/0271678x17713434
复制
发表时间：
2018-09
期刊：
影响因子：
--
通讯作者：
Schmid S
中科院分区：
文献类型：
--
作者：
van Osch MJ;Teeuwisse WM;Chen Z;Suzuki Y;Helle M;Schmid S
随着2015年国际磁共振医学学会（ISMRM）灌注研究组的共识声明和EU-COST行动“痴呆症中的ASL”关于在临床环境中实施动脉自旋标记MRI （ASL）的共识声明的发表，ASL的发展可以被认为已经成熟，并准备好进入临床黄金时期。在这篇综述文章中，我们将讨论ASL的新发展和存在的问题，特别是集中在ASL的量化以及ASL在灌注成像和血流区域测绘中的新技术发展。伪连续ASL （pCASL）中实现的标记效率的不确定性以及动脉传递时间伪影的存在，可以被认为是使用定量脑血流量（CBF）值的主要挑战。ASL的新发展集中在通过时间编码的pCASL和信息内容的多样化，例如通过将4d血管造影与灌注成像相结合，来高效地获取动态ASL图像。目前的血管编码和超选择性pcasl方法已经发展成为易于应用的血流区域测绘方法，提供与当前临床标准数字减影血管造影（DSA）高度相似的相关临床信息。因此，这两种方法似乎都可以用于临床。
With the publication in 2015 of the consensus statement by the perfusion study group of the International Society for Magnetic Resonance in Medicine (ISMRM) and the EU-COST action ‘ASL in dementia’ on the implementation of arterial spin labelling MRI (ASL) in a clinical setting, the development of ASL can be considered to have become mature and ready for clinical prime-time. In this review article new developments and remaining issues will be discussed, especially focusing on quantification of ASL as well as on new technological developments of ASL for perfusion imaging and flow territory mapping. Uncertainty of the achieved labelling efficiency in pseudo-continuous ASL (pCASL) as well as the presence of arterial transit time artefacts, can be considered the main remaining challenges for the use of quantitative cerebral blood flow (CBF) values. New developments in ASL centre around time-efficient acquisition of dynamic ASL-images by means of time-encoded pCASL and diversification of information content, for example by combined 4D-angiography with perfusion imaging. Current vessel-encoded and super-selective pCASL-methodology have developed into easily applied flow-territory mapping methods providing relevant clinical information with highly similar information content as digital subtraction angiography (DSA), the current clinical standard. Both approaches seem therefore to be ready for clinical use.