The defense and signaling role of NADPH oxidases in eukaryotic cells : Review.
The defense and signaling role of NADPH oxidases in eukaryotic cells : Review.
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DOI：
10.1007/s10354-018-0640-4
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发表时间：
2018-09
期刊：
影响因子：
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通讯作者：
Hasek J
中科院分区：
文献类型：
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作者：
Breitenbach M;Rinnerthaler M;Weber M;Breitenbach-Koller H;Karl T;Cullen P;Basu S;Haskova D;Hasek J
这篇简短的综述文章总结了临床和生物化学上已知的七种人NADPH氧化酶。重点放在Nox 2，吞噬细胞防御酶，与慢性肉芽肿病等综合征，以及一些慢性炎症性疾病的催化和调节亚基的突变之间的联系。这些出现矛盾的缺乏活性氧产生所需的第二信使免疫调节。Nox 2和其他六种人类NADPH氧化酶都显示出信号传导功能，除了这些酶在专门的生化反应中的功能外，例如甲状腺素的合成。酿酒酵母细胞也需要NADPH氧化酶来调节肌动蛋白细胞骨架在应激或发育变化时，如假菌丝形成。这篇文章表明，在某些癌细胞中，Nox4也参与了肌动蛋白细胞骨架的重建，这是细胞移动所必需的，因此也是转移所必需的。
This short review article summarizes what is known clinically and biochemically about the seven human NADPH oxidases. Emphasis is put on the connection between mutations in the catalytic and regulatory subunits of Nox2, the phagocyte defense enzyme, with syndromes like chronic granulomatous disease, as well as a number of chronic inflammatory diseases. These arise paradoxically from a lack of reactive oxygen species production needed as second messengers for immune regulation. Both Nox2 and the six other human NADPH oxidases display signaling functions in addition to the functions of these enzymes in specialized biochemical reactions, for instance, synthesis of the hormone thyroxine. NADPH oxidases are also needed by Saccharomyces cerevisiae cells for the regulation of the actin cytoskeleton in times of stress or developmental changes, such as pseudohyphae formation. The article shows that in certain cancer cells Nox4 is also involved in the re-structuring of the actin cytoskeleton, which is required for cell mobility and therefore for metastasis.