FORMATION OF CONTINUOUS COLLAGEN-FIBERS - EVALUATION OF BIOCOMPATIBILITY AND MECHANICAL-PROPERTIES
FORMATION OF CONTINUOUS COLLAGEN-FIBERS - EVALUATION OF BIOCOMPATIBILITY AND MECHANICAL-PROPERTIES
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DOI：
10.1016/0142-9612(90)90150-o
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发表时间：
1990-04-01
期刊：
影响因子：
14
通讯作者：
SILVER, FH
中科院分区：
文献类型：
--
作者：
KATO, YP;SILVER, FH
Reconstituted collagen fibres have potential applications in repair of soft and hard tissues. Preliminary studies conducted in our laboratory suggest that discontinuous reconstituted type I fibres have strengths similar to those of fibres teased from tendons. The purpose of this paper is to report a method for continuous collagen fibre production and the properties of fibres produced. Ultimate tensile mechanical properties and biocompatibility of continuous type I collagen fibres were studied and compared with the properties of fibres produced manually (discontinuous fibres). In general, continuously made cyanamide cross-linked fibres show slightly inferior mechanical properties and faster biodegradation rates compared with manually made fibres because of minor differences in the fibre-formation protocol introduced by design constraints. However, continuous and discontinuous fibres cross-linked with glutaraldehyde had comparable properties. These results demonstrate that production of 50 .mu.m diameter continuous collagen fibre is possible.
