Risk factors and outcome of bacterial infections in cirrhosis
Risk factors and outcome of bacterial infections in cirrhosis
复制标题
DOI：
10.3748/wjg.v20.i10.2542
复制
发表时间：
2014-03-14
影响因子：
4.3
通讯作者：
Stallmach, Andreas
中科院分区：
文献类型：
--
作者：
Bruns, Tony;Zimmermann, Henning W.;Stallmach, Andreas
有活力和无活力的病理性细菌易位促进了功能失调的免疫激活和系统性炎症的自我延续循环，促进了晚期肝硬化的感染和器官衰竭。细菌感染和败血症现在被认为是慢性肝病自然进展中的一个独特阶段，因为它们加速了器官衰竭，并导致失代偿肝硬化的高死亡率。在过去的几十年里，对晚期肝硬化的结构、免疫学和血液动力学病理生理学知识的不断增加尚未转化为显著改善细菌感染的结果。因此，需要早期识别发生感染和感染相关并发症风险最高的患者，以便针对有需要的患者量身定制现有的监测、预防和治疗措施，以改善肝硬化细菌感染的有害后果。（三）2014年百世登出版集团有限公司版权所有。
Viable and non-viable pathological bacterial translocation promote a self-perpetuating circle of dysfunctional immune activation and systemic inflammation facilitating infections and organ failure in advanced cirrhosis. Bacterial infections and sepsis are now recognized as a distinct stage in the natural progression of chronic liver disease as they accelerate organ failure and contribute to the high mortality observed in decompensated cirrhosis. The increasing knowledge of structural, immunological and hemodynamic pathophysiology in advanced cirrhosis has not yet translated into significantly improved outcomes of bacterial infections over the last decades. Therefore, early identification of patients at the highest risk for developing infections and infection-related complications is required to tailor the currently available measures of surveillance, prophylaxis and therapy to the patients in need in order to improve the detrimental outcome of bacterial infections in cirrhosis. (C) 2014 Baishideng Publishing Group Co., Limited. All rights reserved.