Self-reported depression and anti-depressant medication use in essential tremor:: cross-sectional and prospective analyses in a population-based study
Self-reported depression and anti-depressant medication use in essential tremor:: cross-sectional and prospective analyses in a population-based study
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DOI：
10.1111/j.1468-1331.2007.01923.x
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发表时间：
2007-10-01
影响因子：
5.1
通讯作者：
Bermejo-Pareja, F.
中科院分区：
文献类型：
--
作者：
Louis, E. D.;Benito-Leon, J.;Bermejo-Pareja, F.
关于原发性震颤（ET）与抑郁症共病的数据很少。评估ET与自我报告的抑郁症和抗抑郁药物使用的相关性。在西班牙中部进行的一项基于人群的研究中，对参与者进行了基线（1994-1995年）和3年后的评估。在每次评估时评估自我报告的抑郁和抗抑郁药物的使用。在横断面分析中，ET病例报告抑郁的可能性是对照组的两倍[103（43.8%）235例vs 1137例对照组4379例，占26.0%;校正比值比（OR）2.20，95%置信区间（CI）1.66-2.93，P < 0.001]，服用抗抑郁药物的可能性是对照组的3倍[16例（6.8%）vs 113例（2.6%）;校正OR 3.33，95%CI 1.91-5.82，P = 0.001]。在前瞻性分析中，基线自我报告的抑郁（校正后的RR 1.78，95% CI 1.11-2.89，P = 0.018）和基线使用抗抑郁药物（校正后的RR 1.90，95% CI 0.59-6.05，P = 0.28）可能与ET事件相关。ET并不是完全良性的，它似乎与情绪障碍有关。此外，除了作为对疾病表现的继发反应外，这种情绪障碍可能是基础疾病的主要特征。
There are few data on the co-morbidity of essential tremor (ET) with depression. To assess the associations of ET with self-reported depression and antidepressant medication use. In a population-based study in central Spain, participants were evaluated at baseline (1994-1995) and 3 years later. Self-reported depression and use of antidepressant medications were evaluated at each assessment. In cross-sectional analyses, prevalent ET cases were twice more probably than controls to report depression [103 (43.8%) of 235 cases versus 1137 (26.0%) of 4379 controls; adjusted odds ratio (OR) 2.20, 95% confidence interval (CI) 1.66-2.93, P < 0.001] and three times more probably to be taking antidepressant medications [16 (6.8%) cases versus 113 (2.6%) controls; adjusted OR 3.33, 95% CI 1.91-5.82, P = 0.001]. In prospective analyses, baseline self-reported depression (adjusted RR 1.78, 95% CI 1.11-2.89, P = 0.018) and, perhaps, baseline use of antidepressant medication (adjusted RR 1.90, 95% CI 0.59-6.05, P = 0.28) were associated with incident ET. Rather than being totally benign, ET seems to be associated with a mood disorder. Furthermore, as well as being a secondary response to disease manifestations, this mood disorder may be a primary feature of the underlying disease.