Recent trends in multifunctional liposomal nanocarriers for enhanced tumor targeting.
Recent trends in multifunctional liposomal nanocarriers for enhanced tumor targeting.
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DOI：
10.1155/2013/705265
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发表时间：
2013
影响因子：
--
通讯作者：
Torchilin VP
中科院分区：
文献类型：
--
作者：
Perche F;Torchilin VP
脂质体是一种输送系统，在过去的几十年里，它被用于制造各种各样的治疗和显像剂。它们在药代动力学、癌症诊断敏感性和治疗效果方面都比自由形式具有显著优势。癌症的多因子特性和肿瘤微环境的复杂生理特性要求开发多功能纳米载体。多功能脂质体纳米载体应结合长血液循环，以改善所载药物的药代动力学，并相对于健康组织选择性分布到肿瘤病变处，从肿瘤附近的血液中远程控制或肿瘤刺激敏感外渗，内化基元从肿瘤边界和/或肿瘤细胞间隙移动到癌细胞的细胞质中，以有效杀死肿瘤细胞。本文将重点介绍目前使用脂质体进行癌症检测和治疗的策略，并特别关注联合治疗。
Liposomes are delivery systems that have been used to formulate a vast variety of therapeutic and imaging agents for the past several decades. They have significant advantages over their free forms in terms of pharmacokinetics, sensitivity for cancer diagnosis and therapeutic efficacy. The multifactorial nature of cancer and the complex physiology of the tumor microenvironment require the development of multifunctional nanocarriers. Multifunctional liposomal nanocarriers should combine long blood circulation to improve pharmacokinetics of the loaded agent and selective distribution to the tumor lesion relative to healthy tissues, remote-controlled or tumor stimuli-sensitive extravasation from blood at the tumor's vicinity, internalization motifs to move from tumor bounds and/or tumor intercellular space to the cytoplasm of cancer cells for effective tumor cell killing. This review will focus on current strategies used for cancer detection and therapy using liposomes with special attention to combination therapies.